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dc.contributor.authorGarcia, Hernan G.
dc.contributor.authorBrewster, Robert C
dc.contributor.authorPhillips, Rob
dc.date2022-08-11T08:11:00.000
dc.date.accessioned2022-08-23T17:27:52Z
dc.date.available2022-08-23T17:27:52Z
dc.date.issued2016-03-08
dc.date.submitted2016-03-23
dc.identifier.citationIntegr Biol (Camb). 2016 Mar 8. <a href="http://dx.doi.org/10.1039/c6ib00006a">Link to article on publisher's site</a>
dc.identifier.issn1757-9694 (Linking)
dc.identifier.doi10.1039/c6ib00006a
dc.identifier.pmid26952708
dc.identifier.urihttp://hdl.handle.net/20.500.14038/49961
dc.description<p>© The Royal Society of Chemistry 2016. Publisher PDF posted after 12 months as allowed by the publisher's author rights policy at http://www.rsc.org/journals-books-databases/journal-authors-reviewers/licences-copyright-permissions/#author-rights.</p>
dc.description.abstractThe main tenet of physical biology is that biological phenomena can be subject to the same quantitative and predictive understanding that physics has afforded in the context of inanimate matter. However, the inherent complexity of many of these biological processes often leads to the derivation of complex theoretical descriptions containing a plethora of unknown parameters. Such complex descriptions pose a conceptual challenge to the establishment of a solid basis for predictive biology. In this article, we present various exciting examples of how synthetic biology can be used to simplify biological systems and distill these phenomena down to their essential features as a means to enable their theoretical description. Here, synthetic biology goes beyond previous efforts to engineer nature and becomes a tool to bend nature to understand it. We discuss various recent and classic experiments featuring applications of this synthetic approach to the elucidation of problems ranging from bacteriophage infection, to transcriptional regulation in bacteria and in developing embryos, to evolution. In all of these examples, synthetic biology provides the opportunity to turn cells into the equivalent of a test tube, where biological phenomena can be reconstituted and our theoretical understanding put to test with the same ease that these same phenomena can be studied in the in vitro setting.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26952708&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1039/c6ib00006a
dc.subjectsynthetic biology
dc.subjectCell Biology
dc.subjectGenetics and Genomics
dc.subjectIntegrative Biology
dc.subjectMolecular Biology
dc.subjectSystems Biology
dc.titleUsing synthetic biology to make cells tomorrow's test tubes
dc.typeJournal Article
dc.source.journaltitleIntegrative biology : quantitative biosciences from nano to macro
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1079&amp;context=sysbio_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/sysbio_pubs/80
dc.legacy.embargo2017-03-08T00:00:00-08:00
dc.identifier.contextkey8368709
refterms.dateFOA2022-08-23T17:27:53Z
html.description.abstract<p>The main tenet of physical biology is that biological phenomena can be subject to the same quantitative and predictive understanding that physics has afforded in the context of inanimate matter. However, the inherent complexity of many of these biological processes often leads to the derivation of complex theoretical descriptions containing a plethora of unknown parameters. Such complex descriptions pose a conceptual challenge to the establishment of a solid basis for predictive biology. In this article, we present various exciting examples of how synthetic biology can be used to simplify biological systems and distill these phenomena down to their essential features as a means to enable their theoretical description. Here, synthetic biology goes beyond previous efforts to engineer nature and becomes a tool to bend nature to understand it. We discuss various recent and classic experiments featuring applications of this synthetic approach to the elucidation of problems ranging from bacteriophage infection, to transcriptional regulation in bacteria and in developing embryos, to evolution. In all of these examples, synthetic biology provides the opportunity to turn cells into the equivalent of a test tube, where biological phenomena can be reconstituted and our theoretical understanding put to test with the same ease that these same phenomena can be studied in the in vitro setting.</p>
dc.identifier.submissionpathsysbio_pubs/80
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.contributor.departmentProgram in Systems Biology


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