Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2016-12-15Keywords
CSMD3asthma
chronic obstructive pulmonary disease
genome-wide association studies
longitudinal lung function patterns
Genetics and Genomics
Pulmonology
Respiratory Tract Diseases
Systems Biology
Metadata
Show full item recordAbstract
RATIONALE: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease. OBJECTIVES: To determine the genetic underpinnings of lung function patterns in subjects with childhood asthma. METHODS: We performed a genome-wide association study of 581 non-Hispanic white individuals with asthma that were previously classified by patterns of lung function growth and decline (normal growth, normal growth with early decline, reduced growth, and reduced growth with early decline). The strongest association was also measured in two additional cohorts: a small asthma cohort and a large chronic obstructive pulmonary disease metaanalysis cohort. Interaction between the genomic region encompassing the most strongly associated single-nucleotide polymorphism and nearby genes was assessed by two chromosome conformation capture assays. MEASUREMENTS AND MAIN RESULTS: An intergenic single-nucleotide polymorphism (rs4445257) on chromosome 8 was strongly associated with the normal growth with early decline pattern compared with all other pattern groups (P = 6.7 x 10-9; odds ratio, 2.8; 95% confidence interval, 2.0-4.0); replication analysis suggested this variant had opposite effects in normal growth with early decline and reduced growth with early decline pattern groups. Chromosome conformation capture experiments indicated a chromatin interaction between rs4445257 and the promoter of the distal CSMD3 gene. CONCLUSIONS: Early decline in lung function after normal growth is associated with a genetic polymorphism that may also protect against early decline in reduced growth groups. Clinical trial registered with www.clinicaltrials.gov (NCT00000575).Source
Am J Respir Crit Care Med. 2016 Dec 15;194(12):1465-1474. Link to article on publisher's siteDOI
10.1164/rccm.201602-0250OCPermanent Link to this Item
http://hdl.handle.net/20.500.14038/49972PubMed ID
27367781Notes
Full list of authors omitted for brevity. For full list see article.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1164/rccm.201602-0250OC