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    Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation

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    Authors
    Papadaki, Garyfalia
    Kambas, Konstantinos
    Choulaki, Christiana
    Vlachou, Katerina
    Drakos, Elias
    Bertsias, George
    Ritis, Konstantinos
    Boumpas, Dimitrios T.
    Thompson, Paul R
    Verginis, Panayotis
    Sidiropoulos, Prodromos
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    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2016-11-01
    Keywords
    neutrophil extracellular traps
    NETs
    Biochemistry
    Cell Biology
    Enzymes and Coenzymes
    Immune System Diseases
    Immunology and Infectious Disease
    Medicinal-Pharmaceutical Chemistry
    Therapeutics
    
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    Link to Full Text
    https://doi.org/10.1002/eji.201646542
    Abstract
    Aberrant formation of neutrophil extracellular traps (NETs) is a key feature in rheumatoid arthritis (RA) and plays a pivotal role in disease pathogenesis. However, the mechanism through which NETs shape the autoimmune response in RA remains elusive. In this study, we demonstrate that inhibition of peptidylarginine deiminases activity in collagen-induced arthritis (CIA) mouse model significantly reduces NET formation, attenuates clinical disease activity, and prevents joint destruction. Importantly, peptidylarginine deiminase 4 blocking markedly reduces the frequency of collagen-specific IFN-gamma-producing T helper 1 (Th1) cells in the draining lymph nodes of immunized mice. Exposure of dendritic cells (DCs) to CIA-derived NETs induces DC maturation characterized by significant upregulation of costimulatory molecules, as well as elevated secretion of IL-6. Moreover, CIA-NET-treated DCs promote the induction of antigen-specific Th1 cells in vitro. Finally, NETs from RA patients show an increased potential to induce the maturation of DCs from healthy individuals, corroborating the findings obtained in CIA mouse model. Collectively, our findings delineate an important role of NETs in the induction and expansion of Th1 pathogenic cells in CIA through maturation of DCs and reveal a novel role of NETs in shaping the RA-autoimmune response that could be exploited therapeutically.
    Source
    Oct 5. Link to article on publisher's site
    DOI
    10.1002/eji.201646542
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49989
    PubMed ID
    27585946
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/eji.201646542
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