UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDocument Type
Journal ArticlePublication Date
2016-11-01Keywords
neutrophil extracellular trapsNETs
Biochemistry
Cell Biology
Enzymes and Coenzymes
Medicinal-Pharmaceutical Chemistry
Metadata
Show full item recordAbstract
NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time contribute to tissue damage and excessive inflammation. Nicotine is a major toxic agent and has been associated with exacerbated inflammatory diseases. The current study aimed at investigating the role of nicotine, the addictive component of tobacco and electronic cigarettes, on triggering NET formation. We report that nicotine induces neutrophils to release NETs in a dose-dependent manner. Nicotine-induced NET formation is mediated via nicotine acetylcholine receptors, depends on Akt and PAD4 activation, but is Nox2-independent, as demonstrated by pharmacological inhibition of Nox2 and by use of Nox2-deficient mouse neutrophils. These findings demonstrate that nicotine induces NETs, which may in turn contribute to smoking-related diseases.Source
J Leukoc Biol. 2016 Nov;100(5):1105-1112. Epub 2016 Jun 16. Link to article on publisher's siteDOI
10.1189/jlb.3AB0815-379RRPermanent Link to this Item
http://hdl.handle.net/20.500.14038/49991PubMed ID
27312847Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1189/jlb.3AB0815-379RR