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    Nicotine induces neutrophil extracellular traps

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    Authors
    Hosseinzadeh, Ava
    Thompson, Paul R
    Segal, Brahm H.
    Urban, Constantin F.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2016-11-01
    Keywords
    neutrophil extracellular traps
    NETs
    Biochemistry
    Cell Biology
    Enzymes and Coenzymes
    Medicinal-Pharmaceutical Chemistry
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1189/jlb.3AB0815-379RR
    Abstract
    NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time contribute to tissue damage and excessive inflammation. Nicotine is a major toxic agent and has been associated with exacerbated inflammatory diseases. The current study aimed at investigating the role of nicotine, the addictive component of tobacco and electronic cigarettes, on triggering NET formation. We report that nicotine induces neutrophils to release NETs in a dose-dependent manner. Nicotine-induced NET formation is mediated via nicotine acetylcholine receptors, depends on Akt and PAD4 activation, but is Nox2-independent, as demonstrated by pharmacological inhibition of Nox2 and by use of Nox2-deficient mouse neutrophils. These findings demonstrate that nicotine induces NETs, which may in turn contribute to smoking-related diseases.
    Source
    J Leukoc Biol. 2016 Nov;100(5):1105-1112. Epub 2016 Jun 16. Link to article on publisher's site
    DOI
    10.1189/jlb.3AB0815-379RR
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/49991
    PubMed ID
    27312847
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1189/jlb.3AB0815-379RR
    Scopus Count
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    Thompson Lab Publications

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