A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1
UMass Chan AffiliationsDepartment of Biochemistry and Molecular Pharmacology
Document TypeJournal Article
KeywordsAmino Acid Sequence
Molecular Sequence Data
Enzymes and Coenzymes
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AbstractThe dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity.
SourceMol Biosyst. 2011 Jan;7(1):48-51. doi: 10.1039/c0mb00015a. Link to article on publisher's site. Epub 2010 Jul 6.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/50047
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.
Related ResourcesLink to Article in PubMed