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dc.contributor.authorZhao, Yong
dc.contributor.authorIbrahim, Hiba
dc.contributor.authorBailey, Jeffrey A.
dc.contributor.authorLinden, Jeanne
dc.contributor.authorHickson, Elda
dc.contributor.authorHaynes, Stefanie
dc.contributor.authorGreene, Mindy
dc.contributor.authorVauthrin, Michelle
dc.contributor.authorWeinstein, Robert
dc.date2022-08-11T08:11:00.000
dc.date.accessioned2022-08-23T17:28:32Z
dc.date.available2022-08-23T17:28:32Z
dc.date.issued2017-06-01
dc.date.submitted2017-07-18
dc.identifier.citationJ Clin Apher. 2017 Jun;32(3):154-157. doi: 10.1002/jca.21473. Epub 2016 May 13. <a href="https://doi.org/10.1002/jca.21473">Link to article on publisher's site</a>
dc.identifier.issn0733-2459 (Linking)
dc.identifier.doi10.1002/jca.21473
dc.identifier.pmid27172986
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50102
dc.description.abstractTherapeutic plasma exchange (TPE) and hemopoietic progenitor cell (HPC) collection are apheresis procedures that can safely be performed in tandem with hemodialysis. Despite the return of citrate-anticoagulated blood to the patient during HPC collection, it is not necessary to administer supplemental calcium during these procedures because the ionized calcium concentration is restored as the returning blood passes through the dialyzer. It is not known whether this applies to TPE, in which a mixture of blood and pharmaceutical albumin, an avid binder of plasma ionized calcium, is returned to the patient through the dialyzer. We report on three dialysis-dependent patients who required TPE and underwent tandem treatments without supplemental calcium in the apheresis circuit. Overall, ionized calcium fell 4-12% (P = 0.0.024) and patients reported no symptoms of hypocalcemic toxicity. Tandem hemodialysis/TPE can be performed without supplemental calcium in the apheresis circuit. Overall, ionized calcium fell 4-12% (P = 0.0.024) and patients reported no symptoms of hypocalcemic toxicity. Tandem hemodialysis/TPE can be performed without supplemental calcium in the apheresis circuit. J. Clin. Apheresis 32:154-157, 2017. © 2016 Wiley Periodicals, Inc.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27172986&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1002/jca.21473
dc.subjectapheresis; calcium
dc.subjecthumoral rejection
dc.subjectrenal failure
dc.subjecttransplant
dc.subjectHematology
dc.subjectHemic and Immune Systems
dc.subjectHemic and Lymphatic Diseases
dc.titleTherapeutic plasma exchange performed in tandem with hemodialysis without supplemental calcium in the apheresis circuit
dc.typeJournal Article
dc.source.journaltitleJournal of clinical apheresis
dc.source.volume32
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/transfusion_pp/14
dc.identifier.contextkey10444144
html.description.abstract<p>Therapeutic plasma exchange (TPE) and hemopoietic progenitor cell (HPC) collection are apheresis procedures that can safely be performed in tandem with hemodialysis. Despite the return of citrate-anticoagulated blood to the patient during HPC collection, it is not necessary to administer supplemental calcium during these procedures because the ionized calcium concentration is restored as the returning blood passes through the dialyzer. It is not known whether this applies to TPE, in which a mixture of blood and pharmaceutical albumin, an avid binder of plasma ionized calcium, is returned to the patient through the dialyzer. We report on three dialysis-dependent patients who required TPE and underwent tandem treatments without supplemental calcium in the apheresis circuit. Overall, ionized calcium fell 4-12% (P = 0.0.024) and patients reported no symptoms of hypocalcemic toxicity. Tandem hemodialysis/TPE can be performed without supplemental calcium in the apheresis circuit. Overall, ionized calcium fell 4-12% (P = 0.0.024) and patients reported no symptoms of hypocalcemic toxicity. Tandem hemodialysis/TPE can be performed without supplemental calcium in the apheresis circuit. J. Clin. Apheresis 32:154-157, 2017. © 2016 Wiley Periodicals, Inc.</p>
dc.identifier.submissionpathtransfusion_pp/14
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Medicine, Division of Transfusion Medicine
dc.contributor.departmentTransfusion Medicine and Apheresis Service
dc.source.pages154-157


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