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    Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge

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    Authors
    Riley, Margaret A.
    Robinson, Sandra M.
    Roy, Christopher M.
    Dennis, Morgan
    Liu, Vivian
    Dorit, Robert L.
    Document Type
    Journal Article
    Publication Date
    2012-12-01
    Keywords
    Animals
    Anti-Bacterial Agents
    Bacteriuria
    Colicins
    Drug Resistance, Bacterial
    Escherichia coli
    Escherichia coli Infections
    Humans
    Microbial Sensitivity Tests
    UMCCTS funding
    Amino Acids, Peptides, and Proteins
    Biochemistry, Biophysics, and Structural Biology
    Microbiology
    Therapeutics
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    Link to Full Text
    http://dx.doi.org/10.1042/BST20120179
    Abstract
    Pathogenic bacteria resistant to many or all antibiotics already exist. With the decline in microbiological research at pharmaceutical companies, the high rate at which resistance has evolved and spread has demanded a novel approach to addressing this critical human health issue. In the present paper, we propose a new paradigm in antibiotic discovery and development, one that applies ecological and evolutionary theory to design antimicrobial drugs that are more difficult and/or more costly to resist. In essence, we propose to simply adopt the strategies invented and applied by bacteria for hundreds of millions of years. Our research focuses on bacteriocins, powerful biological weapons, and their use as alternative therapeutics in human health.
    Source
    Biochem Soc Trans. 2012 Dec 1;40(6):1438-42. doi: 10.1042/BST20120179.
    DOI
    10.1042/BST20120179.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50302
    PubMed ID
    23176495
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST20120179.
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