A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma
Bertrand, Kimberly A.
Epstein, Mara M.
Rosner, Bernard A.
Giovannucci, Edward L.
Chavarro, Jorge E.
Birmann, Brenda M.
UMass Chan AffiliationsMeyers Primary Care Institute
Department of Medicine
Document TypeAccepted Manuscript
de novo lipogenesis
Cellular and Molecular Physiology
Hemic and Lymphatic Diseases
Pathological Conditions, Signs and Symptoms
Translational Medical Research
MetadataShow full item record
AbstractCirculating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0, and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis.
Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/50308
RightsThis is the peer reviewed version of the following article: Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602, which has been published in final form at https://doi.org/10.1002/ijc.31602. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Posted with a 12-month embargo as specified at https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/licensing/self-archiving.html.