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    A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma

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    Authors
    Chiu, Yu-Han
    Bertrand, Kimberly A.
    Zhang, Shumin
    Laden, Francine
    Epstein, Mara M.
    Rosner, Bernard A.
    Chiuve, Stephanie
    Campos, Hannia
    Giovannucci, Edward L.
    Chavarro, Jorge E.
    Birmann, Brenda M.
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    UMass Chan Affiliations
    Meyers Primary Care Institute
    Department of Medicine
    Document Type
    Accepted Manuscript
    Publication Date
    2018-05-14
    Keywords
    UMCCTS funding
    de novo lipogenesis
    erythrocyte
    fatty acids
    non-Hodgkin lymphoma
    Cancer Biology
    Cellular and Molecular Physiology
    Hemic and Lymphatic Diseases
    Lipids
    Neoplasms
    Pathological Conditions, Signs and Symptoms
    Translational Medical Research
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    Link to Full Text
    https://doi.org/10.1002/ijc.31602
    Abstract
    Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0, and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis.
    Source

    Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602. Link to article on publisher's site

    DOI
    10.1002/ijc.31602
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50308
    PubMed ID
    29756258
    Related Resources

    Link to Article in PubMed

    Rights
    This is the peer reviewed version of the following article: Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602, which has been published in final form at https://doi.org/10.1002/ijc.31602. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Posted with a 12-month embargo as specified at https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/licensing/self-archiving.html.
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.31602
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