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dc.contributor.authorMercado-Lubo, Regino
dc.contributor.authorZhang, Yuanwei
dc.contributor.authorZhao, Liang
dc.contributor.authorRossi, Kyle
dc.contributor.authorWu, Xiang
dc.contributor.authorZou, Yekui
dc.contributor.authorCastillo, Antonio
dc.contributor.authorLeonard, Jack L.
dc.contributor.authorBortell, Rita
dc.contributor.authorGreiner, Dale L.
dc.contributor.authorShultz, Leonard D.
dc.contributor.authorHan, Gang
dc.contributor.authorMcCormick, Beth A.
dc.date2022-08-11T08:11:02.000
dc.date.accessioned2022-08-23T17:29:28Z
dc.date.available2022-08-23T17:29:28Z
dc.date.issued2016-07-25
dc.date.submitted2018-09-11
dc.identifier.citation<p>Nat Commun. 2016 Jul 25;7:12225. doi: 10.1038/ncomms12225. <a href="https://doi.org/10.1038/ncomms12225">Link to article on publisher's site</a></p>
dc.identifier.issn2041-1723 (Linking)
dc.identifier.doi10.1038/ncomms12225
dc.identifier.pmid27452236
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50324
dc.description.abstractSalmonella enterica serotype Typhimurium is a food-borne pathogen that also selectively grows in tumours and functionally decreases P-glycoprotein (P-gp), a multidrug resistance transporter. Here we report that the Salmonella type III secretion effector, SipA, is responsible for P-gp modulation through a pathway involving caspase-3. Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin). On the basis of our finding that the SipA Salmonella effector is fundamental for functionally decreasing P-gp, we engineered a nanoparticle mimic that both overcomes multidrug resistance in cancer cells and increases tumour sensitivity to conventional chemotherapeutics.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27452236&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectUMCCTS funding
dc.subjectCancer Biology
dc.subjectMicrobiology
dc.subjectNanotechnology
dc.subjectTranslational Medical Research
dc.titleA Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
dc.typeJournal Article
dc.source.journaltitleNature communications
dc.source.volume7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1160&amp;context=umccts_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/umccts_pubs/151
dc.identifier.contextkey12824254
refterms.dateFOA2022-08-23T17:29:28Z
html.description.abstract<p>Salmonella enterica serotype Typhimurium is a food-borne pathogen that also selectively grows in tumours and functionally decreases P-glycoprotein (P-gp), a multidrug resistance transporter. Here we report that the Salmonella type III secretion effector, SipA, is responsible for P-gp modulation through a pathway involving caspase-3. Mimicking the ability of Salmonella to reverse multidrug resistance, we constructed a gold nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumulates in tumours but also reduces P-gp at a SipA dose significantly lower than free SipA. Moreover, the Salmonella nanoparticle mimic suppresses tumour growth with a concomitant reduction in P-gp when used with an existing chemotherapeutic drug (that is, doxorubicin). On the basis of our finding that the SipA Salmonella effector is fundamental for functionally decreasing P-gp, we engineered a nanoparticle mimic that both overcomes multidrug resistance in cancer cells and increases tumour sensitivity to conventional chemotherapeutics.</p>
dc.identifier.submissionpathumccts_pubs/151
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages12225


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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.