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dc.contributor.authorKo, Darae
dc.contributor.authorPreis, Sarah R.
dc.contributor.authorLubitz, Steven A.
dc.contributor.authorMcManus, David D.
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorHamburg, Naomi M.
dc.contributor.authorBenjamin, Emelia J.
dc.contributor.authorMitchell, Gary F.
dc.date2022-08-11T08:11:02.000
dc.date.accessioned2022-08-23T17:29:32Z
dc.date.available2022-08-23T17:29:32Z
dc.date.issued2018-03-01
dc.date.submitted2019-04-17
dc.identifier.citation<p>Am J Cardiol. 2018 Mar 1;121(5):596-601. doi: 10.1016/j.amjcard.2017.11.036. Epub 2017 Dec 11. <a href="https://doi.org/10.1016/j.amjcard.2017.11.036">Link to article on publisher's site</a></p>
dc.identifier.issn0002-9149 (Linking)
dc.identifier.doi10.1016/j.amjcard.2017.11.036
dc.identifier.pmid29290367
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50342
dc.description.abstractPrevious studies have reported that orthostatic hypotension (OH) is associated with increased risk of atrial fibrillation (AF). We sought to determine whether the association persists after adjusting for hypertension and other cardiovascular risk factors. We studied the Framingham Heart Study Original cohort participants evaluated between 1981 and 1984 without baseline AF. OH was defined as drop in standing systolic blood pressure (BP) of at least 20 mm Hg or standing diastolic BP of at least 10 mm Hg from their supine values after standing for 2 minutes. We estimated Cox proportional hazards regression models to calculate multivariable-adjusted hazard ratios (HR) for association between OH and risk of incident AF, adjusting for age, sex, seated systolic BP and diastolic BP, resting heart rate, height, weight, current tobacco use, hypertension treatment, diabetes, and history of myocardial infarction and heart failure. Of 1,736 participants (mean age, 71.7 +/- 6.5 years, 60% women), 256 (14.8%) had OH at baseline. During 10 years of follow-up, 224 participants developed new AF. In our multivariable-adjusted model, OH (HR 1.61, 95% confidence interval 1.17 to 2.20) and greater orthostatic decrease in mean arterial pressure (MAP) (HR 1.11, 95% confidence interval 1.02 to 1.22 per 8.6 mm Hg change in MAP) were both associated with higher risk of new AF. In conclusion, in our longitudinal community-based sample, OH and orthostatic decline in MAP were significantly associated with increased risk of incident AF after adjustment for systolic BP, diastolic BP, and hypertension treatment.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=29290367&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843374/
dc.subjectUMCCTS funding
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectCardiovascular System
dc.subjectCirculatory and Respiratory Physiology
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectTranslational Medical Research
dc.titleRelation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study)
dc.typeJournal Article
dc.source.journaltitleThe American journal of cardiology
dc.source.volume121
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/umccts_pubs/169
dc.identifier.contextkey14282383
html.description.abstract<p>Previous studies have reported that orthostatic hypotension (OH) is associated with increased risk of atrial fibrillation (AF). We sought to determine whether the association persists after adjusting for hypertension and other cardiovascular risk factors. We studied the Framingham Heart Study Original cohort participants evaluated between 1981 and 1984 without baseline AF. OH was defined as drop in standing systolic blood pressure (BP) of at least 20 mm Hg or standing diastolic BP of at least 10 mm Hg from their supine values after standing for 2 minutes. We estimated Cox proportional hazards regression models to calculate multivariable-adjusted hazard ratios (HR) for association between OH and risk of incident AF, adjusting for age, sex, seated systolic BP and diastolic BP, resting heart rate, height, weight, current tobacco use, hypertension treatment, diabetes, and history of myocardial infarction and heart failure. Of 1,736 participants (mean age, 71.7 +/- 6.5 years, 60% women), 256 (14.8%) had OH at baseline. During 10 years of follow-up, 224 participants developed new AF. In our multivariable-adjusted model, OH (HR 1.61, 95% confidence interval 1.17 to 2.20) and greater orthostatic decrease in mean arterial pressure (MAP) (HR 1.11, 95% confidence interval 1.02 to 1.22 per 8.6 mm Hg change in MAP) were both associated with higher risk of new AF. In conclusion, in our longitudinal community-based sample, OH and orthostatic decline in MAP were significantly associated with increased risk of incident AF after adjustment for systolic BP, diastolic BP, and hypertension treatment.</p>
dc.identifier.submissionpathumccts_pubs/169
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine
dc.source.pages596-601


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