Retromer promotes immune quiescence by suppressing Spatzle-Toll pathway in Drosophila
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2014-04-01Keywords
UMCCTS fundingAmino Acids, Peptides, and Proteins
Cellular and Molecular Physiology
Hemic and Immune Systems
Immunity
Translational Medical Research
Metadata
Show full item recordAbstract
The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Here we show that retromer, an intracellular protein complex known for regulating vesicle trafficking, functions in modulating the Toll pathway in Drosophila melanogaster. In mutant animals lacking retromer function, the Toll pathway but not JAK-STAT or IMD pathway is activated, triggering both cellular and humoral responses. Genetic epistasis and clonal analysis suggest that retromer regulates a component that acts upstream of Toll. Our data further show that in the mutant the Toll ligand Spatzle has a processing pattern similar to that of after infection. Together, the results suggest a novel function of retromer in regulating Toll pathway and innate immunity at a step that modulates ligand processing or activity.Source
J Cell Physiol. 2014 Apr;229(4):512-520. doi: 10.1002/jcp.24472. Link to article on publisher's site
DOI
10.1002/jcp.24472Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50363PubMed ID
24343480Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/jcp.24472