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    Patient-specific reference values for objective physical function tests: data from the Osteoarthritis Initiative

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    Authors
    Harkey, Matthew S.
    Price, Lori Lyn
    Reid, Kieran F.
    Lo, Grace H.
    Liu, Shao-Hsien
    Lapane, Kate L.
    Dantas, Lucas Ogura
    McAlindon, Timothy E.
    Driban, Jeffrey B.
    UMass Chan Affiliations
    Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Population and Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2020-06-01
    Keywords
    Chair stand
    KL grade
    Knee osteoarthritis
    Muscle strength
    Obesity
    Walking speed
    UMCCTS funding
    Health Services Administration
    Health Services Research
    Musculoskeletal Diseases
    Rheumatology
    Translational Medical Research
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372536/
    Abstract
    INTRODUCTION/OBJECTIVE: We aimed to establish sex-specific reference values of objective physical function tests among individuals with or at risk for knee osteoarthritis (KOA) across subsets of age, radiographic KOA severity, and body mass index (BMI). METHOD: We included Osteoarthritis Initiative participants with data for objective physical function tests, sex, age, BMI, and radiographic KOA severity (Kellgren-Lawrence [KL] grade) at baseline. Objective physical function was quantified with 20-m walk speed, chair-stand speed, 400-m walk time, and knee extension and flexion strength. We created participant characteristic subsets for sex, age, KL grade, and BMI. Reference values were created as percentiles from minimum to maximum in 10% increments for each combination of participant characteristic subsets. Previously established clinically important differences for 20-m walk speed and knee extension strength were used to highlight clinically relevant differences. RESULTS: Objective physical function reference values tables and an interactive reference value table were created across all combinations of sex, age, KL grade, and BMI among 3860 individuals with or at risk for KOA. Clinically relevant differences exist for 20-m walk speed and knee extension strength between males and females across age groups, KL grades, and BMI categories. CONCLUSIONS: Establishing an individual's relative level of objective physical function by comparing their performance to individuals with similar sex, age, KL grade, or BMI may help improve interpretation of physical function performance. The interactive reference value table will provide clinicians and researchers a clinically accessible avenue to use these reference values.Key Points* Since greater age, radiographic knee osteoarthritis severity, and body mass index are all associated with worse objective physical function, reference values should consider the complex inter-play among these patient characteristics.* This study provides objective physical function reference values among subsets of individuals across the spectrum of sex, age groups, radiographic knee osteoarthritis severity, and body mass index categories.* These reference values offer a more patient-centered approach for interpreting an individual's relative level of objective physical function by comparing them to a more homogeneous group of individuals with similar participant characteristics.* We have provided a clinically accessible interactive table that will enable clinicians and researchers to input their patient's data to quickly and efficiently determine a patient's relative objective physical function compared to individual's with similar characteristics.
    Source

    Harkey MS, Price LL, Reid KF, Lo GH, Liu SH, Lapane KL, Dantas LO, McAlindon TE, Driban JB. Patient-specific reference values for objective physical function tests: data from the Osteoarthritis Initiative. Clin Rheumatol. 2020 Jun;39(6):1961-1970. doi: 10.1007/s10067-020-04972-1. Epub 2020 Feb 6. PMID: 32030634; PMCID: PMC7372536. Link to article on publisher's site

    DOI
    10.1007/s10067-020-04972-1
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50381
    PubMed ID
    32030634
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s10067-020-04972-1
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    Population and Quantitative Health Sciences Publications
    UMass Center for Clinical and Translational Science Supported Publications

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