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dc.contributor.authorHariri, Essa
dc.contributor.authorLessard, Darleen M.
dc.contributor.authorGore, Joel M.
dc.contributor.authorRade, Jeffrey J
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:11:02.000
dc.date.accessioned2022-08-23T17:29:44Z
dc.date.available2022-08-23T17:29:44Z
dc.date.issued2020-02-01
dc.date.submitted2020-03-30
dc.identifier.citation<p>Hariri E, Lessard D, Gore J, Rade J, Goldberg R. Are We Optimizing the Use of Dual Antiplatelet Therapy in Patients Hospitalized with Acute Myocardial Infarction? Cardiovasc Revasc Med. 2020 Feb;21(2):182-188. doi: 10.1016/j.carrev.2019.04.024. Epub 2019 May 2. PMID: 31129036; PMCID: PMC6824980. <a href="https://doi.org/10.1016/j.carrev.2019.04.024">Link to article on publisher's site</a></p>
dc.identifier.issn1878-0938 (Linking)
dc.identifier.doi10.1016/j.carrev.2019.04.024
dc.identifier.pmid31129036
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50385
dc.description.abstractBACKGROUND: Dual antiplatelet therapy (DAPT) is a mainstay treatment for hospital survivors of an acute myocardial infarction (AMI). However, there are limited data on the prescribing patterns of DAPT among patients hospitalized with AMI during recent years. OBJECTIVE: To examine decade-long trends (2001-2011) in the use of DAPT versus antiplatelet monotherapy and patient characteristics associated with DAPT use. METHODS: The study population consisted of 2389 adults hospitalized with an initial AMI at all 11 central Massachusetts medical centers on a biennial basis between 2001 and 2011. DAPT was defined as the discharge use of aspirin plus either clopidogrel or prasugrel. Logistic regression analysis was used to identify patient characteristics associated with DAPT use. RESULTS: The average age of the study population was 65 years, and 69% of patients were discharged on DAPT. The use of DAPT at the time of hospital discharge increased from 49% in 2001 to 74% in 2011; this increasing trend was seen across all age groups, both sexes, types of AMI, and in those who underwent a PCI. After multivariable adjustment, patients 65-74 years old (adjusted odds ratio (aOR)=0.53, 95% CI: 0.36-0.80) and those who underwent coronary artery bypass surgery (aOR=0.11, 95% CI: 0.07-0.18) were less likely to have received DAPT, while men (aOR=14.60, 95% CI: 10.66-19.98) and those who underwent cardiac catheterization and stenting (aOR=14.60, 95% CI: 10.66-19.98) were significantly more likely to have received DAPT at discharge than respective comparison groups. CONCLUSIONS: Between 2001 and 2011, the use of DAPT increased markedly among patients hospitalized with AMI. However, a significant proportion of patients were not discharged on this therapy. Greater awareness is needed to incorporate DAPT into the management of patients hospitalized with AMI.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31129036&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/j.carrev.2019.04.024
dc.subjectAcute myocardial infarction
dc.subjectAspirin
dc.subjectClopidogrel
dc.subjectDual antiplatelet therapy
dc.subjectPrasugrel
dc.subjectUMCCTS funding
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectHealth Services Administration
dc.subjectTranslational Medical Research
dc.titleAre We Optimizing the Use of Dual Antiplatelet Therapy in Patients Hospitalized with Acute Myocardial Infarction?
dc.typeJournal Article
dc.source.journaltitleCardiovascular revascularization medicine : including molecular interventions
dc.source.volume21
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/umccts_pubs/211
dc.identifier.contextkey17155439
html.description.abstract<p>BACKGROUND: Dual antiplatelet therapy (DAPT) is a mainstay treatment for hospital survivors of an acute myocardial infarction (AMI). However, there are limited data on the prescribing patterns of DAPT among patients hospitalized with AMI during recent years.</p> <p>OBJECTIVE: To examine decade-long trends (2001-2011) in the use of DAPT versus antiplatelet monotherapy and patient characteristics associated with DAPT use.</p> <p>METHODS: The study population consisted of 2389 adults hospitalized with an initial AMI at all 11 central Massachusetts medical centers on a biennial basis between 2001 and 2011. DAPT was defined as the discharge use of aspirin plus either clopidogrel or prasugrel. Logistic regression analysis was used to identify patient characteristics associated with DAPT use.</p> <p>RESULTS: The average age of the study population was 65 years, and 69% of patients were discharged on DAPT. The use of DAPT at the time of hospital discharge increased from 49% in 2001 to 74% in 2011; this increasing trend was seen across all age groups, both sexes, types of AMI, and in those who underwent a PCI. After multivariable adjustment, patients 65-74 years old (adjusted odds ratio (aOR)=0.53, 95% CI: 0.36-0.80) and those who underwent coronary artery bypass surgery (aOR=0.11, 95% CI: 0.07-0.18) were less likely to have received DAPT, while men (aOR=14.60, 95% CI: 10.66-19.98) and those who underwent cardiac catheterization and stenting (aOR=14.60, 95% CI: 10.66-19.98) were significantly more likely to have received DAPT at discharge than respective comparison groups.</p> <p>CONCLUSIONS: Between 2001 and 2011, the use of DAPT increased markedly among patients hospitalized with AMI. However, a significant proportion of patients were not discharged on this therapy. Greater awareness is needed to incorporate DAPT into the management of patients hospitalized with AMI.</p>
dc.identifier.submissionpathumccts_pubs/211
dc.contributor.departmentDepartment of Population and Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages182-188


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