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dc.contributor.authorChiu, Laura S.
dc.contributor.authorPedley, Alison
dc.contributor.authorMassaro, Joseph M.
dc.contributor.authorBenjamin, Emelia J.
dc.contributor.authorMitchell, Gary F.
dc.contributor.authorMcManus, David D.
dc.contributor.authorAragam, Jayashri
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorCheng, Susan
dc.contributor.authorLong, Michelle T.
dc.date2022-08-11T08:11:02.000
dc.date.accessioned2022-08-23T17:29:54Z
dc.date.available2022-08-23T17:29:54Z
dc.date.issued2020-10-01
dc.date.submitted2021-07-27
dc.identifier.citation<p>Chiu LS, Pedley A, Massaro JM, Benjamin EJ, Mitchell GF, McManus DD, Aragam J, Vasan RS, Cheng S, Long MT. The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study. Liver Int. 2020 Oct;40(10):2445-2454. doi: 10.1111/liv.14600. Epub 2020 Jul 25. PMID: 32654390; PMCID: PMC7669676. <a href="https://doi.org/10.1111/liv.14600">Link to article on publisher's site</a></p>
dc.identifier.issn1478-3223 (Linking)
dc.identifier.doi10.1111/liv.14600
dc.identifier.pmid32654390
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50423
dc.description.abstractBACKGROUND and AIMS: Non-alcoholic fatty liver disease confers increased risk for cardiovascular disease, including heart failure (HF), for reasons that remain unclear. Possible pathways could involve an association of liver fat with cardiac structural or functional abnormalities even after accounting for body size. METHODS: We analysed N = 2356 Framingham Heart Study participants (age 52 +/- 12 years, 52% women) who underwent echocardiography and standardized computed tomography measures of liver fat. RESULTS: In cross-sectional multivariable regression models adjusted for age, gender, cohort and cardiovascular risk factors, liver fat was positively associated with left ventricular (LV) mass (beta = 1.45; 95% confidence interval (CI): 0.01, 2.88), LV wall thickness (beta = 0.01; 95% CI: 0.00, 0.02), mass volume ratio (beta = 0.02; 95% CI 0.01, 0.03), mitral peak velocity (E) (beta = 0.83; 95% CI 0.31, 1.36) and LV filling pressure (E/e' ratio) (beta = 0.16; 95% CI 0.09, 0.23); and inversely associated with global systolic longitudinal strain (beta = 0.20, 95% CI 0.07, 0.33), diastolic annular velocity (e') (beta = -0.12; 95% CI - 0.22, -0.03), and E/A ratio (beta = -0.01; 95% CI - 0.02, -0.00). After additional adjustment for body mass index (BMI), statistical significance was attenuated for all associations except for that of greater liver fat with increased LV filling pressure, a possible precursor to HF (beta = 0.11; 95% CI 0.03, 0.18). CONCLUSION: Increased liver fat was associated with multiple subclinical cardiac dysfunction measures, with most of associations mediated by obesity. Interestingly, the association of liver fat and LV filling pressure was only partially mediated by BMI, suggesting a possible direct effect of liver fat on LV filling pressure. Further confirmatory studies are needed.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32654390&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1111/liv.14600
dc.subjectheart failure
dc.subjectnon-alcoholic fatty liver disease
dc.subjectsubclinical cardiovascular disease
dc.subjectUMCCTS funding
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectDigestive System Diseases
dc.subjectHepatology
dc.subjectTranslational Medical Research
dc.titleThe association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study
dc.typeJournal Article
dc.source.journaltitleLiver international : official journal of the International Association for the Study of the Liver
dc.source.volume40
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/umccts_pubs/246
dc.identifier.contextkey24045756
html.description.abstract<p>BACKGROUND and AIMS: Non-alcoholic fatty liver disease confers increased risk for cardiovascular disease, including heart failure (HF), for reasons that remain unclear. Possible pathways could involve an association of liver fat with cardiac structural or functional abnormalities even after accounting for body size.</p> <p>METHODS: We analysed N = 2356 Framingham Heart Study participants (age 52 +/- 12 years, 52% women) who underwent echocardiography and standardized computed tomography measures of liver fat.</p> <p>RESULTS: In cross-sectional multivariable regression models adjusted for age, gender, cohort and cardiovascular risk factors, liver fat was positively associated with left ventricular (LV) mass (beta = 1.45; 95% confidence interval (CI): 0.01, 2.88), LV wall thickness (beta = 0.01; 95% CI: 0.00, 0.02), mass volume ratio (beta = 0.02; 95% CI 0.01, 0.03), mitral peak velocity (E) (beta = 0.83; 95% CI 0.31, 1.36) and LV filling pressure (E/e' ratio) (beta = 0.16; 95% CI 0.09, 0.23); and inversely associated with global systolic longitudinal strain (beta = 0.20, 95% CI 0.07, 0.33), diastolic annular velocity (e') (beta = -0.12; 95% CI - 0.22, -0.03), and E/A ratio (beta = -0.01; 95% CI - 0.02, -0.00). After additional adjustment for body mass index (BMI), statistical significance was attenuated for all associations except for that of greater liver fat with increased LV filling pressure, a possible precursor to HF (beta = 0.11; 95% CI 0.03, 0.18).</p> <p>CONCLUSION: Increased liver fat was associated with multiple subclinical cardiac dysfunction measures, with most of associations mediated by obesity. Interestingly, the association of liver fat and LV filling pressure was only partially mediated by BMI, suggesting a possible direct effect of liver fat on LV filling pressure. Further confirmatory studies are needed.</p>
dc.identifier.submissionpathumccts_pubs/246
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine
dc.source.pages2445-2454


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