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    The Inverse OARSI-OMERACT Criteria Is a Valid Indicator of the Clinical Worsening of Knee Osteoarthritis: Data From the Osteoarthritis Initiative

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    Authors
    Driban, Jeffrey B.
    Harkey, Matthew S.
    Price, Lori Lyn.
    Lo, Grace H.
    McAlindon, Timothy E.
    UMass Chan Affiliations
    Department of Population and Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2021-03-01
    Keywords
    knee
    osteoarthritis
    pain
    patient-reported outcome measures
    UMCCTS funding
    Musculoskeletal Diseases
    Orthopedics
    Rheumatology
    Translational Medical Research
    
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    Link to Full Text
    https://doi.org/10.3899/jrheum.200145
    Abstract
    OBJECTIVE: We assessed if the inverse Osteoarthritis Research Society International (OARSI) and Outcome Measures in Rheumatology (OMERACT) criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed, as well as future knee replacement. METHODS: We conducted knee-based analyses of data from the Osteoarthritis Initiative. All knees had symptomatic OA: at least doubtful radiographic KOA (Kellgren-Lawrence grade > /= 1) and knee pain > /= 10/100 (Western Ontario and McMaster Universities Osteoarthritis Index pain) at the 12-month visit. The inverse of the OARSI-OMERACT responder criteria depended on knee pain and function, and global assessment of knee impact. We used generalized linear mixed models to assess the relationship of the inverse OARSI-OMERACT criteria over 2 years (i.e., 12-month and 36-month visits) with worsening radiographic severity (any increase in Kellgren-Lawrence grade from 12 months to 36 months) and decline in self-selected 20-m walking speed of > /= 0.1m/s (from 12 months to 36 months). We used a Cox model to assess time to knee replacement during the 6 years after the 36-month visit as an outcome. RESULTS: Among the 1746 analyzed, 19% met the inverse OARSI-OMERACT criteria. Meeting the inverse OARSI-OMERACT criteria was associated with almost double the odds of experiencing concurrent worsening in radiographic KOA severity (OR 1.89, 95% CI 1.32-2.70) or decline in walking speed (OR 1.82, 95% CI 1.37-2.40). A knee meeting the inverse OARSI-OMERACT criteria was more likely to receive a knee replacement after the 36-month visit (23%) compared with a nonresponder (10%; HR 2.54, 95% CI 1.89-3.41). CONCLUSION: The inverse OARSI-OMERACT criteria for worsening among people with KOA had good construct validity in relation to clinically relevant outcomes.
    Source

    Driban JB, Harkey MS, Price LL, Lo GH, McAlindon TE. The Inverse OARSI-OMERACT Criteria Is a Valid Indicator of the Clinical Worsening of Knee Osteoarthritis: Data From the Osteoarthritis Initiative. J Rheumatol. 2021 Mar;48(3):442-446. doi: 10.3899/jrheum.200145. Epub 2020 Jun 15. PMID: 32541081; PMCID: PMC8607982. Link to article on publisher's site

    DOI
    10.3899/jrheum.200145
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50441
    PubMed ID
    32541081
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.3899/jrheum.200145
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    Population and Quantitative Health Sciences Publications
    UMass Center for Clinical and Translational Science Supported Publications

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