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    Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

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    Authors
    Sharma, Upasna
    Conine, Colin C.
    Shea, Jeremy
    Boskovic, Ana
    Derr, Alan G.
    Bing, Xin Y.
    Belleannee, Clemence
    Kucukural, Alper
    Serra, Ryan W.
    Sun, Fengyun
    Song, Lina
    Carone, Benjamin R.
    Ricci, Emiliano P.
    Li, Xin Z.
    Fauquier, Lucas
    Moore, Melissa J.
    Sullivan, Robert
    Mello, Craig C.
    Garber, Manuel
    Rando, Oliver J.
    Show allShow less
    UMass Chan Affiliations
    UMass Metabolic Network
    RNAi Therapeutics Institute
    Program in Bioinformatics and Integrative Biology
    Program in Molecular Medicine
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2016-01-22
    Keywords
    Animals
    Blastocyst
    Diet, Protein-Restricted
    Epididymis
    *Fertilization
    *Gene Expression Regulation
    Male
    Mice
    MicroRNAs
    RNA, Transfer, Gly
    Retroelements
    *Sperm Maturation
    Spermatozoa
    Testis
    UMCCTS funding
    Biochemistry
    Cell Biology
    Cellular and Molecular Physiology
    Developmental Biology
    Molecular Biology
    Molecular Genetics
    Translational Medical Research
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888079/
    Abstract
    Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet affects offspring metabolism. Protein restriction in mice affects small RNA (sRNA) levels in mature sperm, with decreased let-7 levels and increased amounts of 5' fragments of glycine transfer RNAs (tRNAs). In testicular sperm, tRNA fragments are scarce but increase in abundance as sperm mature in the epididymis. Epididymosomes (vesicles that fuse with sperm during epididymal transit) carry RNA payloads matching those of mature sperm and can deliver RNAs to immature sperm in vitro. Functionally, tRNA-glycine-GCC fragments repress genes associated with the endogenous retroelement MERVL, in both embryonic stem cells and embryos. Our results shed light on sRNA biogenesis and its dietary regulation during posttesticular sperm maturation, and they also link tRNA fragments to regulation of endogenous retroelements active in the preimplantation embryo.
    Source

    Science. 2016 Jan 22;351(6271):391-6. doi: 10.1126/science.aad6780. Epub 2015 Dec 31. Link to article on publisher's site

    DOI
    10.1126/science.aad6780
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50490
    PubMed ID
    26721685
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1126/science.aad6780
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    Garber Lab Publications
    Program in Bioinformatics and Integrative Biology Publications
    UMass Center for Clinical and Translational Science Supported Publications

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