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    Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

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    Authors
    Shea, Jeremy
    Serra, Ryan W.
    Carone, Benjamin R.
    Shulha, Hennady P.
    Kucukural, Alper
    Ziller, Michael
    Vallaster, Markus
    Gu, Hongcang
    Tapper, Andrew R.
    Gardner, Paul D.
    Meissner, Alexander
    Garber, Manuel
    Rando, Oliver J.
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    UMass Chan Affiliations
    Gardner Lab
    Tapper Lab
    Department of Psychiatry
    Brudnick Neuropsychiatric Research Institute
    Bioinformatics Core
    Program in Bioinformatics and Integrative Biology
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2015-12-21
    Keywords
    UMCCTS funding
    Biochemistry
    Bioinformatics
    Cell Biology
    Computational Biology
    Developmental Biology
    Genetics
    Genomics
    Molecular Biology
    Translational Medical Research
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691283/
    Abstract
    Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for four pools of sperm samples and for 12 individual sperm samples, as well as 61 genome-scale methylation maps. We find that "epivariation," either stochastic or due to unknown demographic or environmental factors, was a far stronger contributor to the sperm methylome than was the diet consumed. Variation in cytosine methylation was particularly dramatic over tandem repeat families, including ribosomal DNA (rDNA) repeats, but rDNA methylation was strongly correlated with genetic variation in rDNA copy number and was not influenced by paternal diet. These results identify loci of genetic and epigenetic lability in the mammalian genome but argue against a direct role for sperm cytosine methylation in dietary reprogramming of offspring metabolism.
    Source

    Dev Cell. 2015 Dec 21;35(6):750-8. doi: 10.1016/j.devcel.2015.11.024. Link to article on publisher's site

    DOI
    10.1016/j.devcel.2015.11.024
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50493
    PubMed ID
    26702833
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.devcel.2015.11.024
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    UMass Center for Clinical and Translational Science Supported Publications

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