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    Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation

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    Authors
    Sardana, Mayank
    Ogunsua, Adedotun
    Spring, Matthew
    Shaikh, Amir Y.
    Asamoah, Owusu
    Stokken, Glenn
    Browning, Clifford
    Ennis, Cynthia
    Donahue, Kevin
    Rosenthal, Lawrence S.
    Floyd, Kevin C.
    Aurigemma, Gerard P.
    Parikh, Nisha I.
    McManus, David D.
    Show allShow less
    UMass Chan Affiliations
    Division of Cardiovascular Medicine, Department of Medicine
    Document Type
    Journal Article
    Publication Date
    2016-12-01
    Keywords
    UMCCTS funding
    Cardiology
    Cardiovascular Diseases
    Translational Medical Research
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143220/
    Abstract
    INTRODUCTION: Although catheter ablation (CA) for atrial fibrillation (AF) is commonly used to improve symptoms, AF recurrence is common and new tools are needed to better inform patient selection for CA. Left atrial function index (LAFI), an echocardiographic measure of atrial mechanical function, has shown promise as a noninvasive predictor of AF. We hypothesized that LAFI would relate to AF recurrence after CA. METHODS AND RESULTS: All AF patients undergoing index CA were enrolled in a prospective institutional AF Treatment Registry between 2011 and 2014. LAFI was measured post hoc from pre-ablation clinical echocardiographic images in 168 participants. Participants were mostly male (33% female), middle-aged (60 +/- 10 years), obese and had paroxysmal AF (64%). Mean LAFI was 25.9 +/- 17.6. Over 12 months of follow-up, 78 participants (46%) experienced a late AF recurrence. In logistic regression analyses adjusting for factors known to be associated with AF, lower LAFI remained associated with AF recurrence after CA [OR 0.04 (0.01-0.67), P = 0.02]. LAFI discriminated AF recurrence after CA slightly better than CHADS2 (C-statistic 0.60 LAFI, 0.57 CHADS2). For participants with persistent AF, LAFI performed significantly better than CHADS2 score (C statistic = 0.79 LAFI, 0.56 CHADS2, P = 0.02). CONCLUSION: LAFI, an echocardiographic measure of atrial function, is associated with AF recurrence after CA and has improved ability to discriminate AF recurrence as compared to the CHADS-2 score, especially among persistent AF patients. Since LAFI can be calculated using standard 2D echocardiographic images, it may be a helpful tool for predicting AF recurrence.
    Source

    J Cardiovasc Electrophysiol. 2016 Dec;27(12):1411-1419. doi: 10.1111/jce.13086. Epub 2016 Oct 7. Link to article on publisher's site

    DOI
    10.1111/jce.13086
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50516
    PubMed ID
    27569695
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1111/jce.13086
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