Novel Framework for Measuring Whole Knee Osteoarthritis Progression Using Magnetic Resonance Imaging
Authors
Driban, Jeffrey B.Price, Lori Lyn
LaValley, Michael P.
Lo, Grace H.
Zhang, Ming
Harkey, Matthew S.
Canavatchel, Amanda
McAlindon, Timothy E.
UMass Chan Affiliations
UMass Center for Clinical and Translational ScienceDocument Type
Journal ArticlePublication Date
2022-05-01Keywords
UMCCTS fundingMusculoskeletal Diseases
Orthopedics
Radiology
Rheumatology
Translational Medical Research
Metadata
Show full item recordAbstract
OBJECTIVE: We developed and validated a set of composite scores that combine quantitative magnetic resonance imaging (MRI)-based measurements of hyaline cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis into composite scores. METHODS: We selected 300 participants (n = 100 for development cohort; n = 200 for validation cohort) from the Osteoarthritis Initiative with complete clinical, radiographic, and MRI data at baseline and 24 months. We used semiautomated programs to quantify tibiofemoral and patellar cartilage damage, BML volume, and whole-knee effusion-synovitis volume. The candidate composite scores were formed by summing changes from baseline to 24 months based on prespecified methods. We evaluated the candidate composite scores for 1) the ability to differentiate groups with and without knee osteoarthritis progression (17 radiographic and patient-reported definitions), 2) sensitivity to change (standardized response means), and 3) relative performance relating to legacy outcome measures of knee osteoarthritis progression. RESULTS: Three of 13 developed composite scores qualified for testing in the validation cohort (ranked by sensitivity to change): whole-knee cumulative cartilage damage, unweighted total knee score, and BML plus effusion-synovitis volume. Change in cumulative cartilage damage associated with radiographic progression (Kellgren/Lawrence grade: odds ratio [OR] 1.84; joint space width progression: OR 2.11). Changes in the unweighted total knee score (OR 1.97) and BML plus effusion-synovitis score (OR 1.92) associated with Western Ontario and McMaster Universities Osteoarthritis Index knee pain progression. CONCLUSION: Two composite scores emerged, reflecting discrete domains of knee osteoarthritis progression. First, cumulative damage, which is measured by a whole-knee cartilage damage score, reflects the damage accrued over time. Second, dynamic disease activity, which is measured by a BML plus effusion-synovitis score, relates to changes in a patient's state of disease and symptoms.Source
Driban JB, Price LL, LaValley MP, Lo GH, Zhang M, Harkey MS, Canavatchel A, McAlindon TE. Novel Framework for Measuring Whole Knee Osteoarthritis Progression Using Magnetic Resonance Imaging. Arthritis Care Res (Hoboken). 2022 May;74(5):799-808. doi: 10.1002/acr.24512. Epub 2022 Mar 1. PMID: 33202111; PMCID: PMC8631200. Link to article on publisher's site
DOI
10.1002/acr.24512Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50532PubMed ID
33202111Notes
The UMass Center for Clinical and Translational Science (UMCCTS), UL1TR001453, helped fund this study.
Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/acr.24512