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    Effects on metastases of drug therapy during developing and established tumor immunity

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    Authors
    Vaage, J.
    Costanza, Mary E.
    UMass Chan Affiliations
    Department of Medicine, Division of Hematology/Oncology
    Document Type
    Journal Article
    Publication Date
    1983-12-15
    Keywords
    Animals
    Antineoplastic Combined Chemotherapy Protocols
    Cyclophosphamide
    Female
    Fluorouracil
    Immunity, Natural
    Immunosuppression
    Lung Neoplasms
    Mammary Neoplasms, Experimental
    Methotrexate
    Mice
    Mice, Inbred C3H
    Neoplasm Transplantation
    *Transplantation Immunology
    Life Sciences
    Medicine and Health Sciences
    Women's Studies
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    Link to Full Text
    http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910320617/pdf
    Abstract
    The effectiveness of treatment with cyclophosphamide, methotrexate and 5-fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5-fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with established tumor immunity gave added benefit without detectable depression of immune resistance.
    Source
    Int J Cancer. 1983 Dec 15;32(6):759-63.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50607
    PubMed ID
    6654527
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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