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    Effects of combination drug therapy on the subcutaneous and pulmonary growth of a slow and a fast-growing C3H/He mammary carcinoma

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    Authors
    Vaage, J.
    Costanza, Mary E.
    UMass Chan Affiliations
    Department of Medicine, Division of Hematology/Oncology
    Document Type
    Journal Article
    Publication Date
    1979-11-01
    Keywords
    Animals
    Antineoplastic Agents
    Cyclophosphamide
    Doxorubicin
    Drug Resistance
    Drug Therapy, Combination
    Female
    Fluorouracil
    Lung Neoplasms
    Mammary Neoplasms, Experimental
    Methotrexate
    Mice
    Mice, Inbred C3H
    Soft Tissue Neoplasms
    Time Factors
    Cancer Biology
    Cell and Developmental Biology
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    Abstract
    Changes in susceptibility to treatment with Cytoxan, methotrexate, 5-fluorouracil, and Adriamycin, single or in combination, have been studied during the initial and progressive stages of s.c. and pulmonary (via tail vein injection) growth of two transplanted syngeneic C3H/He mammary carcinomas. One tumor was fast growing, reaching a size of 3 mm from a 1-mm s.c. implant in 7 days; the second tumor would grow to the same size in 30 days. The tumor with the slower growth rate was more susceptible to drug treatment, manifested by delayed growth as well as by prevented growth. The slower-growing tumor also remained susceptible longer, when treatment was delayed, than did the faster-growing tumor. Pulmonary growth was more often prevented by drug treatment than was s.c. growth. Tumor implants s.c. which had reached palpable size could be reduced temporarily to impalpable size by effective drug treatment but were rarely cured. The importance of early treatment relative to the time of tumor implantation was indicated when early treatment with a single drug proved more effective than did delayed treatment with a more potent combination of drugs.
    Source
    Cancer Res. 1979 Nov;39(11):4466-71.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50633
    PubMed ID
    498077
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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