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dc.contributor.authorVaage, J.
dc.contributor.authorCostanza, Mary E.
dc.date2022-08-11T08:11:04.000
dc.date.accessioned2022-08-23T17:31:00Z
dc.date.available2022-08-23T17:31:00Z
dc.date.issued1979-11-01
dc.date.submitted2007-07-31
dc.identifier.citationCancer Res. 1979 Nov;39(11):4466-71.
dc.identifier.issn0008-5472 (Print)
dc.identifier.pmid498077
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50633
dc.description.abstractChanges in susceptibility to treatment with Cytoxan, methotrexate, 5-fluorouracil, and Adriamycin, single or in combination, have been studied during the initial and progressive stages of s.c. and pulmonary (via tail vein injection) growth of two transplanted syngeneic C3H/He mammary carcinomas. One tumor was fast growing, reaching a size of 3 mm from a 1-mm s.c. implant in 7 days; the second tumor would grow to the same size in 30 days. The tumor with the slower growth rate was more susceptible to drug treatment, manifested by delayed growth as well as by prevented growth. The slower-growing tumor also remained susceptible longer, when treatment was delayed, than did the faster-growing tumor. Pulmonary growth was more often prevented by drug treatment than was s.c. growth. Tumor implants s.c. which had reached palpable size could be reduced temporarily to impalpable size by effective drug treatment but were rarely cured. The importance of early treatment relative to the time of tumor implantation was indicated when early treatment with a single drug proved more effective than did delayed treatment with a more potent combination of drugs.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=498077&dopt=Abstract">Link to article in PubMed</a>
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCyclophosphamide
dc.subjectDoxorubicin
dc.subjectDrug Resistance
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectFluorouracil
dc.subjectLung Neoplasms
dc.subjectMammary Neoplasms, Experimental
dc.subjectMethotrexate
dc.subjectMice
dc.subjectMice, Inbred C3H
dc.subjectSoft Tissue Neoplasms
dc.subjectTime Factors
dc.subjectCancer Biology
dc.subjectCell and Developmental Biology
dc.titleEffects of combination drug therapy on the subcutaneous and pulmonary growth of a slow and a fast-growing C3H/He mammary carcinoma
dc.typeJournal Article
dc.source.journaltitleCancer research
dc.source.volume39
dc.source.issue11
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1159&amp;context=wfc_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/160
dc.identifier.contextkey330783
refterms.dateFOA2022-08-23T17:31:00Z
html.description.abstract<p>Changes in susceptibility to treatment with Cytoxan, methotrexate, 5-fluorouracil, and Adriamycin, single or in combination, have been studied during the initial and progressive stages of s.c. and pulmonary (via tail vein injection) growth of two transplanted syngeneic C3H/He mammary carcinomas. One tumor was fast growing, reaching a size of 3 mm from a 1-mm s.c. implant in 7 days; the second tumor would grow to the same size in 30 days. The tumor with the slower growth rate was more susceptible to drug treatment, manifested by delayed growth as well as by prevented growth. The slower-growing tumor also remained susceptible longer, when treatment was delayed, than did the faster-growing tumor. Pulmonary growth was more often prevented by drug treatment than was s.c. growth. Tumor implants s.c. which had reached palpable size could be reduced temporarily to impalpable size by effective drug treatment but were rarely cured. The importance of early treatment relative to the time of tumor implantation was indicated when early treatment with a single drug proved more effective than did delayed treatment with a more potent combination of drugs.</p>
dc.identifier.submissionpathwfc_pp/160
dc.contributor.departmentDepartment of Medicine, Division of Hematology/Oncology
dc.source.pages4466-71


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