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dc.contributor.authorStavnezer, Janet
dc.contributor.authorAmemiya, Chris T.
dc.date2022-08-11T08:11:04.000
dc.date.accessioned2022-08-23T17:31:05Z
dc.date.available2022-08-23T17:31:05Z
dc.date.issued2004-08-01
dc.date.submitted2007-09-14
dc.identifier.citationSemin Immunol. 2004 Aug;16(4):257-75. <a href="http://dx.doi.org/10.1016/j.smim.2004.08.005">Link to article on publisher's site</a>
dc.identifier.issn1044-5323 (Print)
dc.identifier.doi10.1016/j.smim.2004.08.005
dc.identifier.pmid15522624
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50650
dc.description.abstractThis review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes from fishes to mammals. Importantly, activation-induced cytidine deaminase (AID), which is essential for CSR and somatic hypermutation, is found in fishes. Although at least some fishes are likely to undergo SHM, CSR is highly unlikely to occur in this group. We discuss the first appearance of CSR in amphibians and how it differs in birds and mammals.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15522624&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.smim.2004.08.005
dc.subjectAnimals
dc.subjectCytidine Deaminase
dc.subject*Evolution, Molecular
dc.subject*Gene Rearrangement
dc.subjectHumans
dc.subject*Immunoglobulin Class Switching
dc.subjectImmunoglobulins
dc.subjectMice
dc.subjectVariation (Genetics)
dc.subjectVertebrates
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectWomen's Studies
dc.titleEvolution of isotype switching
dc.typeJournal Article
dc.source.journaltitleSeminars in immunology
dc.source.volume16
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/176
dc.identifier.contextkey367637
html.description.abstract<p>This review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes from fishes to mammals. Importantly, activation-induced cytidine deaminase (AID), which is essential for CSR and somatic hypermutation, is found in fishes. Although at least some fishes are likely to undergo SHM, CSR is highly unlikely to occur in this group. We discuss the first appearance of CSR in amphibians and how it differs in birds and mammals.</p>
dc.identifier.submissionpathwfc_pp/176
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.source.pages257-75


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