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dc.contributor.authorKaminski, Denise A.
dc.contributor.authorStavnezer, Janet
dc.date2022-08-11T08:11:04.000
dc.date.accessioned2022-08-23T17:31:05Z
dc.date.available2022-08-23T17:31:05Z
dc.date.issued2004-07-21
dc.date.submitted2007-09-14
dc.identifier.citationTrends Genet. 2004 Aug;20(8):337-40. <a href="http://dx.doi.org/10.1016/j.tig.2004.06.008">Link to article on publisher's site</a>
dc.identifier.issn0168-9525 (Print)
dc.identifier.doi10.1016/j.tig.2004.06.008
dc.identifier.pmid15262403
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50652
dc.description.abstractImmunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently, Nambu et al. showed that histone acetylation is induced at switch (S) regions undergoing CSR; however, histone acetylation without accompanying S region transcription is insufficient to attract activation-induced cytidine deaminase (AID), which is required for CSR. They also show that AID can associate with RNA polymerase II. These results support the model that germline transcripts are required to form single-stranded DNA, the AID substrate and further suggest that AID is recruited to S regions by the transcriptional machinery.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15262403&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.tig.2004.06.008
dc.subjectAcetylation
dc.subjectAnimals
dc.subjectCytidine Deaminase
dc.subjectHistones
dc.subjectHumans
dc.subjectImmunoglobulin Class Switching
dc.subjectImmunoglobulin Switch Region
dc.subjectRNA Polymerase II
dc.subjectTranscription, Genetic
dc.subjectGenetics and Genomics
dc.subjectImmunology and Infectious Disease
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleAntibody class switching: uncoupling S region accessibility from transcription
dc.typeJournal Article
dc.source.journaltitleTrends in genetics : TIG
dc.source.volume20
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/178
dc.identifier.contextkey367639
html.description.abstract<p>Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently, Nambu et al. showed that histone acetylation is induced at switch (S) regions undergoing CSR; however, histone acetylation without accompanying S region transcription is insufficient to attract activation-induced cytidine deaminase (AID), which is required for CSR. They also show that AID can associate with RNA polymerase II. These results support the model that germline transcripts are required to form single-stranded DNA, the AID substrate and further suggest that AID is recruited to S regions by the transcriptional machinery.</p>
dc.identifier.submissionpathwfc_pp/178
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.source.pages337-40


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