Immunoglobulin genes: generating diversity with AID and UNG

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Authors
Storb, Ursula
Stavnezer, Janet
UMass Chan Affiliations
Department of Molecular Genetics and Microbiology
Document Type
Journal Article
Publication Date
2002-10-29
Keywords
Animals
Cytidine Deaminase
*DNA Glycosylases
*Genes, Immunoglobulin
Mice
N-Glycosyl Hydrolases
Uracil-DNA Glycosidase
Life Sciences
Medicine and Health Sciences
Women's Studies

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http://dx.doi.org/10.1016/S0960-9822(02)01247-2
Abstract
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
Source

Curr Biol. 2002 Oct 29;12(21):R725-7.
DOI
10.1016/S0960-9822(02)01247-2
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50656
PubMed ID
12419200
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