Does activation-induced deaminase initiate antibody diversification by DNA deamination
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UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyDocument Type
Journal ArticlePublication Date
2002-11-01Keywords
Antibody DiversityB-Lymphocytes
Cytidine Deaminase
*Gene Conversion
*Genes, Immunoglobulin
Humans
Immunoglobulin M
Immunoglobulin Variable Region
Life Sciences
Medicine and Health Sciences
Women's Studies
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Show full item recordAbstract
Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region segments, three processes that diversify antibodies during immune responses. Although AID has homology to RNA-editing enzymes, three recent reports suggest it could initiate the diversification processes by deaminating cytidine residues within the antibody genes themselves.Source
Trends Genet. 2002 Nov;18(11):541-3.
DOI
10.1016/S0168-9525(02)02799-3Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50657PubMed ID
12414176Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/S0168-9525(02)02799-3