Does activation-induced deaminase initiate antibody diversification by DNA deamination
UMass Chan AffiliationsDepartment of Molecular Genetics and Microbiology
Document TypeJournal Article
Immunoglobulin Variable Region
Medicine and Health Sciences
MetadataShow full item record
AbstractActivation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region segments, three processes that diversify antibodies during immune responses. Although AID has homology to RNA-editing enzymes, three recent reports suggest it could initiate the diversification processes by deaminating cytidine residues within the antibody genes themselves.
Trends Genet. 2002 Nov;18(11):541-3.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/50657