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    Immunology. A touch of antibody class

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    Authors
    Stavnezer, Janet
    UMass Chan Affiliations
    Department of Molecular Genetics and Microbiology
    Document Type
    Journal Article
    Publication Date
    2000-05-12
    Keywords
    Animals
    B-Lymphocytes
    Cytokines
    DNA
    Genes, Immunoglobulin
    *Immunoglobulin Class Switching
    Immunoglobulin Heavy Chains
    *Immunoglobulin Switch Region
    Mice
    Mice, Transgenic
    Models, Genetic
    *Nucleic Acid Hybridization
    RNA
    RNA Splicing
    Recombination, Genetic
    Ribonuclease H, Calf Thymus
    Templates, Genetic
    Transcription, Genetic
    Life Sciences
    Medicine and Health Sciences
    Women's Studies
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    Link to Full Text
    http://dx.doi.org/10.1126/science.288.5468.984
    Abstract
    When B cells, the antibody producing cells of the body, encounter antigen they switch from producing immunoglobulin (Ig) M to producing other classes of antibody (IgG, IgA or IgE), the class selected depending on the type of immune response needed. But the way in which B cells skillfully switch from one antibody class to another is still not clear although it is known to involve recombination between genes. In a Perspective, Stavnezer explains how formation of hybrids between RNA transcripts (transcribed from the heavy chain gene to which the cell will switch) and the DNA template at crucial switch sequences in the genome regulates class switching (Tracy et al.). It is possible that an as yet unidentified endonuclease digests the hybrid thereby creating the DNA ends that will be joined together.
    Source
    Science. 2000 May 12;288(5468):984-5. Link to article on publisher's site
    DOI
    10.1126/science.288.5468.984
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50665
    PubMed ID
    10841719
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.288.5468.984
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications

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