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dc.contributor.authorLorenz, W.
dc.contributor.authorSchable, K. F.
dc.contributor.authorThiebe, R.
dc.contributor.authorStavnezer, Janet
dc.contributor.authorZachau, H. G.
dc.date2022-08-11T08:11:04.000
dc.date.accessioned2022-08-23T17:31:19Z
dc.date.available2022-08-23T17:31:19Z
dc.date.issued1988-05-01
dc.date.submitted2007-09-14
dc.identifier.citation<p>Mol Immunol. 1988 May;25(5):479-84.</p>
dc.identifier.issn0161-5890 (Print)
dc.identifier.doi10.1016/0161-5890(88)90168-X
dc.identifier.pmid3137458
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50705
dc.description.abstractThe structure of one of the V kappa gene-containing regions of the locus coding for the human immunoglobulin light chains of the kappa type is described. This so-called B region contains three genes: B1, B2 and B3. According to its sequence B1 is a pseudogene which does not fit well into the present subgroup classification. In lymphoid cell lines the B1 gene region is frequently deleted. B2 and B3 are the previously reported EV15 and V kappa IV genes. The transcriptional polarity of the B1 gene is found to be opposite to one of the B2 and B3 genes. This observation together with the fact that the B region is proximal to the J kappa C kappa gene segment leads to the conclusions to the mechanism of the V kappa-J kappa recombination and allows us to explain the formation of the recombination products in a particular cell line by two consecutive inversions.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3137458&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttp://dx.doi.org/10.1016/0161-5890(88)90168-X
dc.subjectBase Sequence
dc.subjectDNA
dc.subject*Genes, Immunoglobulin
dc.subjectHumans
dc.subjectImmunoglobulin Joining Region
dc.subjectImmunoglobulin Variable Region
dc.subjectImmunoglobulin kappa-Chains
dc.subjectMolecular Sequence Data
dc.subjectPseudogenes
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectWomen's Studies
dc.titleThe J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities
dc.typeJournal Article
dc.source.journaltitleMolecular immunology
dc.source.volume25
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/231
dc.identifier.contextkey367692
html.description.abstract<p>The structure of one of the V kappa gene-containing regions of the locus coding for the human immunoglobulin light chains of the kappa type is described. This so-called B region contains three genes: B1, B2 and B3. According to its sequence B1 is a pseudogene which does not fit well into the present subgroup classification. In lymphoid cell lines the B1 gene region is frequently deleted. B2 and B3 are the previously reported EV15 and V kappa IV genes. The transcriptional polarity of the B1 gene is found to be opposite to one of the B2 and B3 genes. This observation together with the fact that the B region is proximal to the J kappa C kappa gene segment leads to the conclusions to the mechanism of the V kappa-J kappa recombination and allows us to explain the formation of the recombination products in a particular cell line by two consecutive inversions.</p>
dc.identifier.submissionpathwfc_pp/231
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.source.pages479-84


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