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dc.contributor.authorMatthews, Karen A.
dc.contributor.authorSantoro, Nanette
dc.contributor.authorLasley, William L.
dc.contributor.authorChang, Yuefang
dc.contributor.authorCrawford, Sybil L.
dc.contributor.authorPasternak, Richard C.
dc.contributor.authorSutton-Tyrrell, Kim
dc.contributor.authorSowers, Maryfran
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:11Z
dc.date.available2022-08-23T17:32:11Z
dc.date.issued2006-02-24
dc.date.submitted2007-01-25
dc.identifier.citationJ Clin Endocrinol Metab. 2006 May;91(5):1789-95. Epub 2006 Feb 21. <a href="http://dx.doi.org/10.1210/jc.2005-1057">Link to article on publisher's site</a>
dc.identifier.issn0021-972X (Print)
dc.identifier.doi10.1210/jc.2005-1057
dc.identifier.pmid16492698
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50901
dc.description.abstractCONTEXT: Menstrual cycle characteristics may be associated with cardiovascular disease (CVD) risk. OBJECTIVE: The objective of this study was to describe the relationships between menstrual cycle characteristics and daily reproductive hormone measures with CVD risk factors in middle-aged women. DESIGN AND SETTING: Cross-sectional associations were examined between CVD risk factors and urinary LH, FSH, estrone conjugates, and pregnanediol glucuronide (Pdg) measured across one menstrual cycle or 50 d. PARTICIPANTS: Menstruating women (n = 500) who were free from diabetes or past stroke or heart attack enrolled in the Daily Hormone Study-Study of Women's Health across the Nation were studied. MAIN OUTCOME MEASURES: Body mass index (BMI), blood pressure, hemostatic, and metabolic factors were measured. RESULTS: Few differences existed in risk factors between women with evidence of luteal activity and those with no evidence of luteal activity. Associations between elevated CVD risk factors and long cycle length were reduced substantially by age and BMI adjustments. Those with lower estrone conjugate and PdG averaged across the follicular phase had higher waist circumference, triglycerides, insulin, plasminogen activator inhibitor type-1, tissue type plasminogen activator-antigen, and factor VIIc levels in age- and BMI-adjusted analyses (P < 0.05). CONCLUSIONS: In midlife menstruating women, a longer cycle length was related to CVD risk factors, in large part through their common association with BMI. More favorable levels of metabolic and hemostatic factors were associated with higher levels of follicular-phase estrogen, a pattern consistent with a more competent ovary, and higher levels of follicular-phase PdG, perhaps of adrenal origin. Metabolic and hemostatic factors may be sensitive to hormonal variation during the early perimenopausal transition.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16492698&dopt=Abstract">Link to article in PubMed</a>
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectBlood Pressure
dc.subjectBody Composition
dc.subjectBody Mass Index
dc.subjectCardiovascular Diseases
dc.subjectCohort Studies
dc.subjectEstrone
dc.subjectFemale
dc.subjectFollicle Stimulating Hormone
dc.subjectFollicular Phase
dc.subjectGonadal Steroid Hormones
dc.subjectHumans
dc.subjectInflammation
dc.subjectLipids
dc.subjectLuteal Phase
dc.subjectLuteinizing Hormone
dc.subjectMenopause
dc.subjectMenstrual Cycle
dc.subjectMiddle Aged
dc.subjectPregnanediol
dc.subjectRisk Factors
dc.subjectWeight Gain
dc.subjectCardiology
dc.subjectObstetrics and Gynecology
dc.subjectPreventive Medicine
dc.titleRelation of cardiovascular risk factors in women approaching menopause to menstrual cycle characteristics and reproductive hormones in the follicular and luteal phases
dc.typeJournal Article
dc.source.journaltitleThe Journal of clinical endocrinology and metabolism
dc.source.volume91
dc.source.issue5
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1042&amp;context=wfc_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/43
dc.identifier.contextkey245187
refterms.dateFOA2022-08-23T17:32:11Z
html.description.abstract<p>CONTEXT: Menstrual cycle characteristics may be associated with cardiovascular disease (CVD) risk.</p> <p>OBJECTIVE: The objective of this study was to describe the relationships between menstrual cycle characteristics and daily reproductive hormone measures with CVD risk factors in middle-aged women.</p> <p>DESIGN AND SETTING: Cross-sectional associations were examined between CVD risk factors and urinary LH, FSH, estrone conjugates, and pregnanediol glucuronide (Pdg) measured across one menstrual cycle or 50 d.</p> <p>PARTICIPANTS: Menstruating women (n = 500) who were free from diabetes or past stroke or heart attack enrolled in the Daily Hormone Study-Study of Women's Health across the Nation were studied.</p> <p>MAIN OUTCOME MEASURES: Body mass index (BMI), blood pressure, hemostatic, and metabolic factors were measured. RESULTS: Few differences existed in risk factors between women with evidence of luteal activity and those with no evidence of luteal activity. Associations between elevated CVD risk factors and long cycle length were reduced substantially by age and BMI adjustments. Those with lower estrone conjugate and PdG averaged across the follicular phase had higher waist circumference, triglycerides, insulin, plasminogen activator inhibitor type-1, tissue type plasminogen activator-antigen, and factor VIIc levels in age- and BMI-adjusted analyses (P < 0.05).</p> <p>CONCLUSIONS: In midlife menstruating women, a longer cycle length was related to CVD risk factors, in large part through their common association with BMI. More favorable levels of metabolic and hemostatic factors were associated with higher levels of follicular-phase estrogen, a pattern consistent with a more competent ovary, and higher levels of follicular-phase PdG, perhaps of adrenal origin. Metabolic and hemostatic factors may be sensitive to hormonal variation during the early perimenopausal transition.</p>
dc.identifier.submissionpathwfc_pp/43
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages1789-95


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