Calcium plus vitamin D supplementation and the risk of fractures
dc.contributor.author | Jackson, Rebecca D. | |
dc.contributor.author | LaCroix, Andrea Z. | |
dc.contributor.author | Gass, Margery | |
dc.contributor.author | Wallace, Robert B. | |
dc.contributor.author | Robbins, John | |
dc.contributor.author | Lewis, Cora E. | |
dc.contributor.author | Bassford, Tamsen | |
dc.contributor.author | Beresford, Shirley A. A. | |
dc.contributor.author | Black, Henry R. | |
dc.contributor.author | Blanchette, Patricia L. | |
dc.contributor.author | Bonds, Denise E. | |
dc.contributor.author | Brunner, Robert L. | |
dc.contributor.author | Brzyski, Robert G. | |
dc.contributor.author | Caan, Bette J. | |
dc.contributor.author | Cauley, Jane A. | |
dc.contributor.author | Chlebowski, Rowan T. | |
dc.contributor.author | Cummings, Steven R. | |
dc.contributor.author | Granek, Iris A. | |
dc.contributor.author | Hays, Jennifer | |
dc.contributor.author | Heiss, Gerardo | |
dc.contributor.author | Hendrix, Susan L. | |
dc.contributor.author | Howard, Barbara V. | |
dc.contributor.author | Hsia, Judith | |
dc.contributor.author | Hubbell, F. Allan | |
dc.contributor.author | Johnson, Karen C. | |
dc.contributor.author | Judd, Howard | |
dc.contributor.author | Kotchen, Jane Morley | |
dc.contributor.author | Kuller, Lewis H. | |
dc.contributor.author | Langer, Robert D. | |
dc.contributor.author | Lasser, Norman L. | |
dc.contributor.author | Limacher, Marian C. | |
dc.contributor.author | Ludlam, Shari E. | |
dc.contributor.author | Manson, JoAnn E. | |
dc.contributor.author | Margolis, Karen L. | |
dc.contributor.author | McGowan, Joan | |
dc.contributor.author | Ockene, Judith K. | |
dc.contributor.author | O'Sullivan, Mary Jo | |
dc.contributor.author | Phillips, Lawrence | |
dc.contributor.author | Prentice, Ross L. | |
dc.contributor.author | Sarto, Gloria E. | |
dc.contributor.author | Stefanick, Marcia L. | |
dc.contributor.author | Van Horn, Linda | |
dc.contributor.author | Wactawski-Wende, Jean | |
dc.contributor.author | Whitlock, Evelyn | |
dc.contributor.author | Anderson, Garnet L. | |
dc.contributor.author | Assaf, Annlouise R. | |
dc.contributor.author | Barad, David H. | |
dc.date | 2022-08-11T08:11:05.000 | |
dc.date.accessioned | 2022-08-23T17:32:14Z | |
dc.date.available | 2022-08-23T17:32:14Z | |
dc.date.issued | 2006-02-16 | |
dc.date.submitted | 2008-03-04 | |
dc.identifier.citation | N Engl J Med. 2006 Feb 16;354(7):669-83. <a href="http://dx.doi.org/10.1056/NEJMoa055218">Link to article on publisher's site</a> | |
dc.identifier.issn | 1533-4406 (Electronic) | |
dc.identifier.doi | 10.1056/NEJMoa055218 | |
dc.identifier.pmid | 16481635 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/50908 | |
dc.description.abstract | BACKGROUND: The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal. METHODS: We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental [corrected] calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an average follow-up period of 7.0 years. Bone density was measured at three WHI centers. RESULTS: Hip bone density was 1.06 percent higher in the calcium plus vitamin D group than in the placebo group (PCONCLUSIONS: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones. (ClinicalTrials.gov number, NCT00000611.). | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16481635&dopt=Abstract ">Link to article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1056/NEJMoa055218 | |
dc.rights | Copyright © 2006 Massachusetts Medical Society. PDF posted as allowed by the publisher’s Author Permissions policy at https://www.nejm.org/author-center/permissions. | |
dc.subject | Aged | |
dc.subject | Bone Density | |
dc.subject | Calcium | |
dc.subject | Calcium Carbonate | |
dc.subject | Double-Blind Method | |
dc.subject | Drug Combinations | |
dc.subject | Drug Interactions | |
dc.subject | Estrogen Replacement Therapy | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Fractures, Bone | |
dc.subject | Hip Fractures | |
dc.subject | Humans | |
dc.subject | Kidney Calculi | |
dc.subject | Middle Aged | |
dc.subject | Patient Compliance | |
dc.subject | Postmenopause | |
dc.subject | Proportional Hazards Models | |
dc.subject | Risk | |
dc.subject | Spinal Fractures | |
dc.subject | Vitamin D | |
dc.subject | Preventive Medicine | |
dc.title | Calcium plus vitamin D supplementation and the risk of fractures | |
dc.type | Journal Article | |
dc.source.journaltitle | The New England journal of medicine | |
dc.source.volume | 354 | |
dc.source.issue | 7 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/wfc_pp/436 | |
dc.identifier.contextkey | 447492 | |
refterms.dateFOA | 2024-03-07T16:50:00Z | |
html.description.abstract | <p>BACKGROUND: The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal.</p> <p>METHODS: We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental [corrected] calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an average follow-up period of 7.0 years. Bone density was measured at three WHI centers.</p> <p>RESULTS: Hip bone density was 1.06 percent higher in the calcium plus vitamin D group than in the placebo group (PCONCLUSIONS: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones. (ClinicalTrials.gov number, NCT00000611.).</p> | |
dc.identifier.submissionpath | wfc_pp/436 | |
dc.contributor.department | Department of Medicine, Division of Preventive and Behavioral Medicine | |
dc.source.pages | 669-83 |