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dc.contributor.authorJackson, Rebecca D.
dc.contributor.authorLaCroix, Andrea Z.
dc.contributor.authorGass, Margery
dc.contributor.authorWallace, Robert B.
dc.contributor.authorRobbins, John
dc.contributor.authorLewis, Cora E.
dc.contributor.authorBassford, Tamsen
dc.contributor.authorBeresford, Shirley A. A.
dc.contributor.authorBlack, Henry R.
dc.contributor.authorBlanchette, Patricia L.
dc.contributor.authorBonds, Denise E.
dc.contributor.authorBrunner, Robert L.
dc.contributor.authorBrzyski, Robert G.
dc.contributor.authorCaan, Bette J.
dc.contributor.authorCauley, Jane A.
dc.contributor.authorChlebowski, Rowan T.
dc.contributor.authorCummings, Steven R.
dc.contributor.authorGranek, Iris A.
dc.contributor.authorHays, Jennifer
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorHendrix, Susan L.
dc.contributor.authorHoward, Barbara V.
dc.contributor.authorHsia, Judith
dc.contributor.authorHubbell, F. Allan
dc.contributor.authorJohnson, Karen C.
dc.contributor.authorJudd, Howard
dc.contributor.authorKotchen, Jane Morley
dc.contributor.authorKuller, Lewis H.
dc.contributor.authorLanger, Robert D.
dc.contributor.authorLasser, Norman L.
dc.contributor.authorLimacher, Marian C.
dc.contributor.authorLudlam, Shari E.
dc.contributor.authorManson, JoAnn E.
dc.contributor.authorMargolis, Karen L.
dc.contributor.authorMcGowan, Joan
dc.contributor.authorOckene, Judith K.
dc.contributor.authorO'Sullivan, Mary Jo
dc.contributor.authorPhillips, Lawrence
dc.contributor.authorPrentice, Ross L.
dc.contributor.authorSarto, Gloria E.
dc.contributor.authorStefanick, Marcia L.
dc.contributor.authorVan Horn, Linda
dc.contributor.authorWactawski-Wende, Jean
dc.contributor.authorWhitlock, Evelyn
dc.contributor.authorAnderson, Garnet L.
dc.contributor.authorAssaf, Annlouise R.
dc.contributor.authorBarad, David H.
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:14Z
dc.date.available2022-08-23T17:32:14Z
dc.date.issued2006-02-16
dc.date.submitted2008-03-04
dc.identifier.citationN Engl J Med. 2006 Feb 16;354(7):669-83. <a href="http://dx.doi.org/10.1056/NEJMoa055218">Link to article on publisher's site</a>
dc.identifier.issn1533-4406 (Electronic)
dc.identifier.doi10.1056/NEJMoa055218
dc.identifier.pmid16481635
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50908
dc.description.abstractBACKGROUND: The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal. METHODS: We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental [corrected] calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an average follow-up period of 7.0 years. Bone density was measured at three WHI centers. RESULTS: Hip bone density was 1.06 percent higher in the calcium plus vitamin D group than in the placebo group (PCONCLUSIONS: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones. (ClinicalTrials.gov number, NCT00000611.).
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16481635&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1056/NEJMoa055218
dc.rightsCopyright © 2006 Massachusetts Medical Society. PDF posted as allowed by the publisher’s Author Permissions policy at https://www.nejm.org/author-center/permissions.
dc.subjectAged
dc.subjectBone Density
dc.subjectCalcium
dc.subjectCalcium Carbonate
dc.subjectDouble-Blind Method
dc.subjectDrug Combinations
dc.subjectDrug Interactions
dc.subjectEstrogen Replacement Therapy
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectFractures, Bone
dc.subjectHip Fractures
dc.subjectHumans
dc.subjectKidney Calculi
dc.subjectMiddle Aged
dc.subjectPatient Compliance
dc.subjectPostmenopause
dc.subjectProportional Hazards Models
dc.subjectRisk
dc.subjectSpinal Fractures
dc.subjectVitamin D
dc.subjectPreventive Medicine
dc.titleCalcium plus vitamin D supplementation and the risk of fractures
dc.typeJournal Article
dc.source.journaltitleThe New England journal of medicine
dc.source.volume354
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/436
dc.identifier.contextkey447492
refterms.dateFOA2024-03-07T16:50:00Z
html.description.abstract<p>BACKGROUND: The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal.</p> <p>METHODS: We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental [corrected] calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an average follow-up period of 7.0 years. Bone density was measured at three WHI centers.</p> <p>RESULTS: Hip bone density was 1.06 percent higher in the calcium plus vitamin D group than in the placebo group (PCONCLUSIONS: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones. (ClinicalTrials.gov number, NCT00000611.).</p>
dc.identifier.submissionpathwfc_pp/436
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages669-83


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