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dc.contributor.authorRobinson, Jennifer G.
dc.contributor.authorWallace, Robert B.
dc.contributor.authorLimacher, Marian C.
dc.contributor.authorSato, Alicia
dc.contributor.authorCochrane, Barbara B.
dc.contributor.authorWassertheil-Smoller, Sylvia
dc.contributor.authorOckene, Judith K.
dc.contributor.authorBlanchette, Patricia L.
dc.contributor.authorKo, Marcia G.
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:16Z
dc.date.available2022-08-23T17:32:16Z
dc.date.issued2006-12-15
dc.date.submitted2008-03-04
dc.identifier.citationJ Womens Health (Larchmt). 2006 Dec;15(10):1151-60. <a href="http://dx.doi.org/10.1089/jwh.2006.15.1151">Link to article on publisher's site</a>
dc.identifier.issn1540-9996 (Print)
dc.identifier.doi10.1089/jwh.2006.15.1151
dc.identifier.pmid17199456
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50916
dc.description.abstractBACKGROUND: Women are more likely than men to have nonspecific chest pain (NSCP) symptoms. The long-term outcomes in women discharged with a diagnosis of NSCP are unknown. METHODS: The Women's Health Initiative Observational Study enrolled postmenopausal women aged 50-79 years. After excluding those with prior cardiovascular disease (CVD), 83,622 women were studied. NSCP cases were defined as having an initial primary hospital discharge diagnosis of NSCP (ICD-9 codes 786.50, 786.51, 786.59) without a prior diagnosis of coronary heart disease (CHD). Risks of subsequent CHD events were estimated from Cox proportional hazard ratio (HR) models stratified by clinic and adjusted for baseline age, cardiovascular risk factors, and hormone use. RESULTS: Over an average of 8 years of follow-up, 11% (230 of 2,092) of women with NSCP experienced a cardiovascular event compared with 9.5% (7,724 of 81,530) who did not. Compared with women without a hospitalization for NSCP during follow-up, those with NSCP had a greater than 2-fold higher risk of a subsequent hospitalization for clinically diagnosed angina (HR 2.18, 95% CI 1.66-2.86) and at least a 1.5-fold higher risk of nonfatal myocardial infarction (MI) (HR 1.59, 1.10-2.31), revascularization (HR 1.67, 1.28-2.20), and congestive heart failure (HR 1.75, 1.27-2.41). Women with NSCP who subsequently experienced a CHD event were more likely to be over age 65 or to have cardiovascular risk factors. CONCLUSIONS: Older women discharged with a diagnosis of NSCP may be at increased risk of CHD morbidity. Further research is needed to replicate these findings in other populations.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17199456&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1089/jwh.2006.15.1151
dc.subjectAged
dc.subjectCardiovascular Diseases
dc.subjectand control
dc.subjectChest Pain
dc.subjectCohort Studies
dc.subjectConfidence Intervals
dc.subjectFemale
dc.subjectHealth Status
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectOdds Ratio
dc.subjectPostmenopause
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectStroke
dc.subjectUnited States
dc.subject*Women's Health
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectWomen's Studies
dc.titleElderly women diagnosed with nonspecific chest pain may be at increased cardiovascular risk
dc.typeJournal Article
dc.source.journaltitleJournal of women's health (2002)
dc.source.volume15
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/443
dc.identifier.contextkey447499
html.description.abstract<p>BACKGROUND: Women are more likely than men to have nonspecific chest pain (NSCP) symptoms. The long-term outcomes in women discharged with a diagnosis of NSCP are unknown.</p> <p>METHODS: The Women's Health Initiative Observational Study enrolled postmenopausal women aged 50-79 years. After excluding those with prior cardiovascular disease (CVD), 83,622 women were studied. NSCP cases were defined as having an initial primary hospital discharge diagnosis of NSCP (ICD-9 codes 786.50, 786.51, 786.59) without a prior diagnosis of coronary heart disease (CHD). Risks of subsequent CHD events were estimated from Cox proportional hazard ratio (HR) models stratified by clinic and adjusted for baseline age, cardiovascular risk factors, and hormone use.</p> <p>RESULTS: Over an average of 8 years of follow-up, 11% (230 of 2,092) of women with NSCP experienced a cardiovascular event compared with 9.5% (7,724 of 81,530) who did not. Compared with women without a hospitalization for NSCP during follow-up, those with NSCP had a greater than 2-fold higher risk of a subsequent hospitalization for clinically diagnosed angina (HR 2.18, 95% CI 1.66-2.86) and at least a 1.5-fold higher risk of nonfatal myocardial infarction (MI) (HR 1.59, 1.10-2.31), revascularization (HR 1.67, 1.28-2.20), and congestive heart failure (HR 1.75, 1.27-2.41). Women with NSCP who subsequently experienced a CHD event were more likely to be over age 65 or to have cardiovascular risk factors.</p> <p>CONCLUSIONS: Older women discharged with a diagnosis of NSCP may be at increased risk of CHD morbidity. Further research is needed to replicate these findings in other populations.</p>
dc.identifier.submissionpathwfc_pp/443
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages1151-60


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