Show simple item record

dc.contributor.authorDerby, Carol A.
dc.contributor.authorCrawford, Sybil L.
dc.contributor.authorPasternak, Richard C.
dc.contributor.authorSowers, Mary Fran R.
dc.contributor.authorSternfeld, Barbara
dc.contributor.authorMatthews, Karen A.
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:20Z
dc.date.available2022-08-23T17:32:20Z
dc.date.issued2009-06-01
dc.date.submitted2010-03-01
dc.identifier.citation<p>Am J Epidemiol. 2009 Jun 1;169(11):1352-61. Epub 2009 Apr 8. <a href="http://dx.doi.org/10.1093/aje/kwp043">Link to article on publisher's site</a></p>
dc.identifier.issn0002-9262 (Linking)
dc.identifier.doi10.1093/aje/kwp043
dc.identifier.pmid19357323
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50928
dc.description.abstractFew studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (> or =130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=19357323&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727246/
dc.subjectAdult
dc.subjectAge Factors
dc.subject*Body Weight
dc.subjectEstradiol
dc.subjectFemale
dc.subjectFollicle Stimulating Hormone
dc.subjectHumans
dc.subjectLinear Models
dc.subjectLipids
dc.subjectLongitudinal Studies
dc.subjectMenopause
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectUnited States
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectWomen's Studies
dc.titleLipid changes during the menopause transition in relation to age and weight: the Study of Women's Health Across the Nation
dc.typeJournal Article
dc.source.journaltitleAmerican journal of epidemiology
dc.source.volume169
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/456
dc.identifier.contextkey1182190
html.description.abstract<p>Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (> or =130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.</p>
dc.identifier.submissionpathwfc_pp/456
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages1352-61


This item appears in the following Collection(s)

Show simple item record