Circulating angiogenic factors in singleton vs multiple-gestation pregnancies
Name:
Publisher version
UMass Chan Affiliations
Department of ObstetricsDepartment of Medicine, Division of Preventive and Behavioral Medicine
Document Type
Journal ArticlePublication Date
2008-02-01Keywords
AdultAngiogenic Proteins
Case-Control Studies
Cohort Studies
Female
Gestational Age
Humans
Pre-Eclampsia
Pregnancy
Pregnancy ProteinsPregnancy Trimester, ThirdPregnancy, High-RiskPregnancy, MultipleVascular Endothelial Growth Factor Receptor-1Life SciencesMedicine and Health SciencesObstetrics and Gynecology
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OBJECTIVE: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. STUDY DESIGN: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. RESULTS: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. CONCLUSION: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.Source
Am J Obstet Gynecol. 2008 Feb;198(2):200.e1-7. Link to article on publisher's siteDOI
10.1016/j.ajog.2007.08.042Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50939PubMed ID
18226624Related Resources
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