Angiogenic factors for the prediction of preeclampsia in high-risk women
AuthorsMoore Simas, Tiffany A.
Crawford, Sybil L.
Solitro, Matthew J.
Frost, Sara C.
Meyer, Bruce A.
Maynard, Sharon E.
UMass Chan AffiliationsDepartment of Obstetrics and Gynecology
Department of Medicine, Division of Preventive and Behavioral Medicine
Angiogenesis Inducing Agents
Predictive Value of Tests
Vascular Endothelial Growth Factor Receptor-1
Medicine and Health Sciences
Obstetrics and Gynecology
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AbstractOBJECTIVE: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women. STUDY DESIGN: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay. RESULTS: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk. CONCLUSIONS: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.
SourceAm J Obstet Gynecol. 2007 Sep;197(3):244.e1-8. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/50947
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