Low-fat dietary pattern and lipoprotein risk factors: the Women's Health Initiative Dietary Modification Trial
Authors
Howard, Barbara V.Curb, J. David
Eaton, Charles B.
Kooperberg, Charles L.
Ockene, Judith K.
Kostis, John B.
Pettinger, Mary
Rajkovic, Aleksandar
Robinson, Jennifer G.
Rossouw, Jacques E.
Sarto, Gloria E.
Shikany, James M.
Van Horn, Linda
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2010-02-17
Metadata
Show full item recordAbstract
BACKGROUND: The Women's Health Initiative Dietary Modification Trial tested the effects on chronic disease of a dietary pattern lower in fat and higher in vegetables, fruit, and grains. OBJECTIVE: The objective was to evaluate the effects of dietary carbohydrate changes on lipids and lipoprotein composition. DESIGN: Postmenopausal women were randomly assigned to an intervention or a comparison group for a mean of 8.1 y. Lipoprotein analyses and subclasses were based on subsamples of 2730 and 209 participants, respectively. RESULTS: At year 6, the total reported fat intake was 7.8% lower and carbohydrate intake was 7.6% higher in the intervention group than in the comparison group. Triglyceride change between groups differed by 2.3, 3.8, and -0.8 mg/dL at 1, 3, and 6 y, respectively, and HDL-cholesterol change differed by -1.6, -0.7, and -1.0 mg/dL at 1, 3, and 6 y, respectively. Changes did not differ by age, ethnicity, or obesity. In diabetic intervention women who were white, the triglyceride difference between the intervention and comparison groups was 33.8 mg/dL, whereas in black women with diabetes (n = 50 in the intervention group; n = 83 in the comparison group), the triglyceride difference was 6.4 mg/dL (P for 3-factor interaction = 0.049). No significant changes were observed in apolipoprotein or lipoprotein particles. Reductions in LDL cholesterol varied by quartile of reported lowering of saturated or trans fat. CONCLUSIONS: The replacement of 7-8% of fat intake with complex carbohydrates over 6 y was not associated with clinically adverse effects on triglycerides, HDL cholesterol, or lipoprotein subclasses. Diabetic white women with higher triglyceride concentrations may have greater increases in triglycerides.Source
Am J Clin Nutr. 2010 Feb 17. Link to article on publisher's site
DOI
10.3945/ajcn.2009.28034Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50974PubMed ID
20164311Related Resources
ae974a485f413a2113503eed53cd6c53
10.3945/ajcn.2009.28034