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dc.contributor.authorGreen, Sharone
dc.contributor.authorEnnis, Francis A.
dc.contributor.authorMathew, Anuja
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:37Z
dc.date.available2022-08-23T17:32:37Z
dc.date.issued2011-02-11
dc.date.submitted2012-06-22
dc.identifier.citation<p>Vaccine. 2011 Feb 11;29(8):1666-76. Epub 2010 Dec 31. <a href="http://dx.doi.org/10.1016/j.vaccine.2010.12.036">Link to article on publisher's site</a></p>
dc.identifier.issn0264-410X (Linking)
dc.identifier.doi10.1016/j.vaccine.2010.12.036
dc.identifier.pmid21195803
dc.identifier.urihttp://hdl.handle.net/20.500.14038/50990
dc.description.abstractSince long-term immunity is a critical component of any effective vaccine, we compared over a 15-month period, the strength, durability and specificity of immunity of an attenuated smallpox vaccine Modified Vaccinia Ankara (MVA) to the New York City Board of Health (NYCBH) vaccine. The frequencies of CD8(+) T cells to an immunodominant CD8 T cell epitope B8R(20-27) remained remarkably stable in mice given either MVA or NYCBH. Both groups were also protected from a lethal intranasal challenge with Western Reserve strain of vaccinia virus (VACV-WR). Cytokine responses to virus-specific peptides were detectable with significant boosting upon challenge. Expression of most phenotypic markers that define antigen-specific memory CD8 T cells was similar while CD27 was differentially expressed on lung-specific T cells compared to the spleen. Our data indicate robust vaccinia-specific CD8(+) T cell recall responses to lethal secondary challenge in protected mice with no apparent effect of age on T cell pools established much earlier in life.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21195803&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034797/
dc.subjectAdoptive Transfer
dc.subjectAging
dc.subjectAnimals
dc.subjectAntigens, CD27
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectEpitopes, T-Lymphocyte
dc.subjectFemale
dc.subjectImmunity, Cellular
dc.subjectImmunodominant Epitopes
dc.subject*Immunologic Memory
dc.subjectInterferon-gamma
dc.subjectLung
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectNeutralization Tests
dc.subjectSmallpox
dc.subjectSmallpox Vaccine
dc.subjectSpleen
dc.subjectVaccinia virus
dc.subjectViral Load
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectWomen's Studies
dc.titleLong term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines
dc.typeJournal Article
dc.source.journaltitleVaccine
dc.source.volume29
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/522
dc.identifier.contextkey3017579
html.description.abstract<p>Since long-term immunity is a critical component of any effective vaccine, we compared over a 15-month period, the strength, durability and specificity of immunity of an attenuated smallpox vaccine Modified Vaccinia Ankara (MVA) to the New York City Board of Health (NYCBH) vaccine. The frequencies of CD8(+) T cells to an immunodominant CD8 T cell epitope B8R(20-27) remained remarkably stable in mice given either MVA or NYCBH. Both groups were also protected from a lethal intranasal challenge with Western Reserve strain of vaccinia virus (VACV-WR). Cytokine responses to virus-specific peptides were detectable with significant boosting upon challenge. Expression of most phenotypic markers that define antigen-specific memory CD8 T cells was similar while CD27 was differentially expressed on lung-specific T cells compared to the spleen. Our data indicate robust vaccinia-specific CD8(+) T cell recall responses to lethal secondary challenge in protected mice with no apparent effect of age on T cell pools established much earlier in life.</p>
dc.identifier.submissionpathwfc_pp/522
dc.contributor.departmentCenter for Infectious Disease and Vaccine Research
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages1666-76


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