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    Enhanced humoral and hla-a2-restricted dengue virus-specific t cell responses in humanized blt nsg mice

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    Authors
    Jaiswal, Smita
    UMass Chan Affiliations
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    2012-03-02
    Keywords
    Life Sciences
    Medicine and Health Sciences
    Women's Studies
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385033/
    Abstract
    Dengue is a mosquito borne viral disease of humans, and animal models that recapitulate human immune responses and/or dengue pathogenesis are needed to understand the pathogenesis of the disease. We recently described an animal model for dengue virus (DENV) infection using humanized NOD-scid IL2rgamma(null) mice (NSG) engrafted with cord blood hematopoietic stem cells (HSC). We sought to further improve this model by co-transplantation of human fetal thymus and liver tissues into NSG (BLT-NSG) mice. Enhanced DENV-specific antibody titers were found in the sera of BLT-NSG mice compared to human cord blood HSC-engrafted NSG mice. Furthermore, B cells generated during the acute phase and in memory from splenocytes of immunized BLT-NSG mice secreted DENV-specific IgM antibodies with neutralizing activity. Human T cells in engrafted BLT-NSG mice secreted IFN-gamma in response to overlapping DENV peptide pools and HLA-A2 restricted peptides. BLT-NSG mice will provide a much-needed platform to assess human immune responses to DENV vaccines and the effects of prior immunity on subsequent DENV infections. (c) 2012 The Authors. Immunology (c) 2012 Blackwell Publishing Ltd, Immunology.
    Source

    Immunology. 2012 Mar 2. doi: 10.1111/j.1365-2567.2012.03585.x. Link to article on publisher's site

    DOI
    10.1111/j.1365-2567.2012.03585.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/50997
    PubMed ID
    22384859
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2567.2012.03585.x
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