A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
Authors
Vanasse, Gary J.Jeong, Jee-Yeong
Tate, Janet
Bathulapalli, Harini
Anderson, Damon
Steen, Hanno
Fleming, Mark D.
Mattocks, Kristin M
Telenti, Amalio
Fellay, Jacques
Justice, Amy C.
Berliner, Nancy
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2011-11-01Keywords
AdultAged
Anemia
Anti-Retroviral Agents
Cohort Studies
Female
Genetic Predisposition to Disease
Genetic Variation
HIV Infections
Hemoglobins
Humans
Leptin
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Prevalence
Promoter Regions, Genetic
Veterans
Genetic Phenomena
Immune System Diseases
Metadata
Show full item recordAbstract
To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.Source
DOI
10.1182/blood-2011-06-362194Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51026PubMed ID
21926355Related Resources
ae974a485f413a2113503eed53cd6c53
10.1182/blood-2011-06-362194