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    A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease

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    Authors
    Vanasse, Gary J.
    Jeong, Jee-Yeong
    Tate, Janet
    Bathulapalli, Harini
    Anderson, Damon
    Steen, Hanno
    Fleming, Mark D.
    Mattocks, Kristin M
    Telenti, Amalio
    Fellay, Jacques
    Justice, Amy C.
    Berliner, Nancy
    Show allShow less
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2011-11-01
    Keywords
    Adult
    Aged
    Anemia
    Anti-Retroviral Agents
    Cohort Studies
    Female
    Genetic Predisposition to Disease
    Genetic Variation
    HIV Infections
    Hemoglobins
    Humans
    Leptin
    Linkage Disequilibrium
    Male
    Middle Aged
    Polymorphism, Single Nucleotide
    Prevalence
    Promoter Regions, Genetic
    Veterans
    Genetic Phenomena
    Immune System Diseases
    Show allShow less
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217345/
    Abstract
    To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.
    Source

    Sep 16. Link to article on publisher's site

    DOI
    10.1182/blood-2011-06-362194
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51026
    PubMed ID
    21926355
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1182/blood-2011-06-362194
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