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dc.contributor.authorVanasse, Gary J.
dc.contributor.authorJeong, Jee-Yeong
dc.contributor.authorTate, Janet
dc.contributor.authorBathulapalli, Harini
dc.contributor.authorAnderson, Damon
dc.contributor.authorSteen, Hanno
dc.contributor.authorFleming, Mark D.
dc.contributor.authorMattocks, Kristin M
dc.contributor.authorTelenti, Amalio
dc.contributor.authorFellay, Jacques
dc.contributor.authorJustice, Amy C.
dc.contributor.authorBerliner, Nancy
dc.date2022-08-11T08:11:05.000
dc.date.accessioned2022-08-23T17:32:47Z
dc.date.available2022-08-23T17:32:47Z
dc.date.issued2011-11-01
dc.date.submitted2014-06-19
dc.identifier.citation<p>Sep 16. <a href="http://dx.doi.org/10.1182/blood-2011-06-362194">Link to article on publisher's site</a></p>
dc.identifier.issn0006-4971 (Linking)
dc.identifier.doi10.1182/blood-2011-06-362194
dc.identifier.pmid21926355
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51026
dc.description.abstractTo study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21926355&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217345/
dc.subjectAdult
dc.subjectAged
dc.subjectAnemia
dc.subjectAnti-Retroviral Agents
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectHIV Infections
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectLeptin
dc.subjectLinkage Disequilibrium
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPrevalence
dc.subjectPromoter Regions, Genetic
dc.subjectVeterans
dc.subjectGenetic Phenomena
dc.subjectImmune System Diseases
dc.titleA polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
dc.typeJournal Article
dc.source.journaltitleBlood
dc.source.volume118
dc.source.issue20
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/wfc_pp/561
dc.identifier.contextkey5705553
html.description.abstract<p>To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.</p>
dc.identifier.submissionpathwfc_pp/561
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages5401-8


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