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dc.contributor.advisorYang Xiangen_US
dc.contributor.authorWang, Fei
dc.date.accessioned2022-09-19T17:41:36Z
dc.date.available2022-09-19T17:41:36Z
dc.date.issued2022-06-30
dc.identifier.doi10.13028/5w64-cg40en_US
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51126
dc.description.abstractWhy closely related neuronal types differ in their axon regenerative abilities remains elusive. Here, I demonstrate gliotransmission determines such a difference in Drosophila larval sensory neurons. Axotomy activates ensheathing glia, which signal to regenerative neurons through the gliotransmitter adenosine, to mount regenerative programs including neuronal activity and Ras. Surprisingly, ensheathing glia do not signal to non-regenerative neurons. Such neuronal type-specific responses to gliotransmission result from specific expression of adenosine receptors in regenerative neurons. Disrupting gliotransmission impedes regeneration of regenerative neurons. Strikingly, reconstitution of gliotransmission in non-regenerative neurons enables them to regenerate. Furthermore, activation of an adenosine receptor in adult mice promotes both regeneration and survival of retinal ganglion cells, uncovering a conserved pro-regenerative role of adenosine receptors. My studies demonstrate gliotransmission as a novel mechanism by which glia instruct axon regeneration, with neuronal type-specificity, and suggest targeting purinergic signaling as a new strategy for mammalian central nervous system repair.en_US
dc.language.isoen_USen_US
dc.publisherUMass Chan Medical Schoolen_US
dc.rightsCopyright © 2022 Fei Wang.en_US
dc.rights.uriAll Rights Reserveden_US
dc.subjectgliotransmissionen_US
dc.subjectaxon regenerationen_US
dc.subjectgliaen_US
dc.titleGliotransmission Orchestrates Neuronal Type-specific Axon Regenerationen_US
dc.typeDoctoral Dissertationen_US
dc.contributor.departmentNeurobiologyen_US
dc.contributor.departmentYang Xiang Lab
dc.description.thesisprogramNeuroscienceen_US
dc.identifier.orcid0000-0002-7969-904Xen_US


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