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    Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence in Massachusetts Estimated from Newborn Screening Specimens

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    Authors
    Ma, Kevin C
    Hale, Jaime E
    Grad, Yonatan H
    Alter, Galit
    Luzuriaga, Katherine
    Eaton, Roger B
    Fischinger, Stephanie
    Kaur, Devinder
    Brody, Robin
    Siddiqui, Sameed M
    Leach, Dylan
    Brown, Catherine M
    Klevens, R Monina
    Madoff, Lawrence
    Comeau, Anne Marie
    Show allShow less
    UMass Chan Affiliations
    Center for Clinical and Translational Science
    Pediatrics
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2022-08-24
    Keywords
    SARS-CoV-2
    newborn screening
    seroprevalence
    UMCCTS funding
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1093/cid/ciac158
    Abstract
    Background: Estimating the cumulative incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for setting public health policies. We leveraged deidentified Massachusetts newborn screening specimens as an accessible, retrospective source of maternal antibodies for estimating statewide seroprevalence in a nontest-seeking population. Methods: We analyzed 72 117 newborn specimens collected from November 2019 through December 2020, representing 337 towns and cities across Massachusetts. Seroprevalence was estimated for the Massachusetts population after correcting for imperfect test specificity and nonrepresentative sampling using Bayesian multilevel regression and poststratification. Results: Statewide seroprevalence was estimated to be 0.03% (90% credible interval [CI], 0.00-0.11) in November 2019 and rose to 1.47% (90% CI: 1.00-2.13) by May 2020, following sustained SARS-CoV-2 transmission in the spring. Seroprevalence plateaued from May onward, reaching 2.15% (90% CI: 1.56-2.98) in December 2020. Seroprevalence varied substantially by community and was particularly associated with community percent non-Hispanic Black (β = .024; 90% CI: 0.004-0.044); i.e., a 10% increase in community percent non-Hispanic Black was associated with 27% higher odds of seropositivity. Seroprevalence estimates had good concordance with reported case counts and wastewater surveillance for most of 2020, prior to the resurgence of transmission in winter. Conclusions: Cumulative incidence of SARS-CoV-2 protective antibody in Massachusetts was low as of December 2020, indicating that a substantial fraction of the population was still susceptible. Maternal seroprevalence data from newborn screening can inform longitudinal trends and identify cities and towns at highest risk, particularly in settings where widespread diagnostic testing is unavailable.
    Source
    Ma KC, Hale JE, Grad YH, Alter G, Luzuriaga K, Eaton RB, Fischinger S, Kaur D, Brody R, Siddiqui SM, Leach D, Brown CM, Klevens RM, Madoff L, Comeau AM. Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence in Massachusetts Estimated from Newborn Screening Specimens. Clin Infect Dis. 2022 Aug 24;75(1):e105-e113. doi: 10.1093/cid/ciac158. PMID: 35213690; PMCID: PMC8903451.
    DOI
    10.1093/cid/ciac158
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51145
    PubMed ID
    35213690
    Notes
    This article is based on a previously available preprint in medRxiv. doi: https://doi.org/10.1101/2021.10.29.21265678.
    Rights
    © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciac158
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