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    Racial differences in the association of accelerated aging with future cardiovascular events and all-cause mortality: the coronary artery risk development in young adults study, 2007-2018

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    Authors
    Forrester, Sarah N
    Zmora, Rachel
    Schreiner, Pamela J
    Jacobs, David R
    Roger, Veronique L
    Thorpe, Roland J
    Kiefe, Catarina I
    UMass Chan Affiliations
    Population and Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2022-07-01
    Keywords
    Health disparities
    accelerated aging
    biological aging
    cardiovascular disease
    UMCCTS funding
    
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    Link to Full Text
    https://doi.org/10.1080/13557858.2020.1839021
    Abstract
    Objective: Variability of Cardiovascular disease (CVD) risk, including racial difference, is not fully accounted for by the variability of traditional CVD risk factors. We used a multiple biomarker model as a framework to explore known racial differences in CVD burden. Design: We measured associations between accelerated aging (AccA) measured by a combination of biomarkers, and cardiovascular morbidity and all-cause mortality using data from the Coronary Artery Risk Development in Young Adults study (CARDIA). AccA was defined as the difference between biological age, calculated using biomarkers with the Klemera and Doubal method, and chronological age. Using logistic regression, we assessed overall and race-specific associations between AccA, CVD, and all-cause mortality. Results: Among our cohort of 2959 Black or White middle-aged adults, after adjustment, a one-year increase in AccA was associated with increased odds of CVD (Odds Ratio (OR) = 1.04; 95% CI: 1.02, 1.06), stroke (OR = 1.12; 95% CI: 1.07, 1.17), and all-cause mortality (OR = 1.05; 95% CI: 1.02, 1.08). We did not find significant overall racial differences, but we did find race by sex differences where Black men differed markedly from White men in the strength of association with CVD (OR = 1.06, 95% CI: 1.01, 1.12). Conclusions: We provide evidence that AccA is associated with future CVD.
    Source
    Forrester SN, Zmora R, Schreiner PJ, Jacobs DR Jr, Roger VL, Thorpe RJ Jr, Kiefe CI. Racial differences in the association of accelerated aging with future cardiovascular events and all-cause mortality: the coronary artery risk development in young adults study, 2007-2018. Ethn Health. 2022 Jul;27(5):997-1009. doi: 10.1080/13557858.2020.1839021. Epub 2020 Nov 21. PMID: 33222499; PMCID: PMC8137718.
    DOI
    10.1080/13557858.2020.1839021
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51148
    PubMed ID
    33222499
    ae974a485f413a2113503eed53cd6c53
    10.1080/13557858.2020.1839021
    Scopus Count
    Collections
    Population and Quantitative Health Sciences Publications
    UMass Center for Clinical and Translational Science Supported Publications

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