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dc.contributor.authorXu, Jinrui
dc.contributor.authorPratt, Henry E
dc.contributor.authorMoore, Jill E.
dc.contributor.authorGerstein, Mark B.
dc.contributor.authorWeng, Zhiping
dc.date.accessioned2022-10-07T16:48:19Z
dc.date.available2022-10-07T16:48:19Z
dc.date.issued2022-09-09
dc.identifier.citationXu J, Pratt HE, Moore JE, Gerstein MB, Weng Z. Building integrative functional maps of gene regulation. Hum Mol Genet. 2022 Sep 9:ddac195. doi: 10.1093/hmg/ddac195. Epub ahead of print. PMID: 36083269.en_US
dc.identifier.eissn1460-2083
dc.identifier.doi10.1093/hmg/ddac195en_US
dc.identifier.pmid36083269
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51155
dc.description.abstractEvery cell in the human body inherits a copy of the same genetic information. The three billion base pairs of DNA in the human genome, and the roughly 50 000 coding and non-coding genes they contain, must thus encode all the complexity of human development and cell and tissue type diversity. Differences in gene regulation, or the modulation of gene expression, enable individual cells to interpret the genome differently to carry out their specific functions. Here we discuss recent and ongoing efforts to build gene regulatory maps, which aim to characterize all sequences in a genome for their roles in regulating gene expression. Many researchers and consortia have identified such regulatory elements using functional assays and evolutionary analyses; we discuss the results, strengths, and shortcomings of their approaches. We also discuss new techniques the field can leverage and emerging challenges it will face while striving to build gene regulatory maps of ever-increasing resolution and comprehensiveness.en_US
dc.language.isoenen_US
dc.relation.ispartofHuman Molecular Geneticsen_US
dc.relation.urlhttps://doi.org/10.1093/hmg/ddac195en_US
dc.rights© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.en_US
dc.subjectGene Regulatory Mapsen_US
dc.titleBuilding integrative functional maps of gene regulationen_US
dc.typeJournal Articleen_US
dc.source.journaltitleHuman molecular genetics
dc.source.countryEngland
dc.identifier.journalHuman molecular genetics
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentProgram in Bioinformatics and Integrative Biologyen_US


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