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dc.contributor.authorKe, Ruian
dc.contributor.authorMartinez, Pamela P
dc.contributor.authorSmith, Rebecca L
dc.contributor.authorGibson, Laura L
dc.contributor.authorAchenbach, Chad J
dc.contributor.authorMcFall, Sally
dc.contributor.authorQi, Chao
dc.contributor.authorJacob, Joshua
dc.contributor.authorDembele, Etienne
dc.contributor.authorBundy, Camille
dc.contributor.authorSimons, Lacy M
dc.contributor.authorOzer, Egon A
dc.contributor.authorHultquist, Judd F
dc.contributor.authorLorenzo-Redondo, Ramon
dc.contributor.authorOpdycke, Anita K
dc.contributor.authorHawkins, Claudia
dc.contributor.authorMurphy, Robert L
dc.contributor.authorMirza, Agha
dc.contributor.authorConte, Madison
dc.contributor.authorGallagher, Nicholas
dc.contributor.authorLuo, Chun Huai
dc.contributor.authorJarrett, Junko
dc.contributor.authorConte, Abigail
dc.contributor.authorZhou, Ruifeng
dc.contributor.authorFarjo, Mireille
dc.contributor.authorRendon, Gloria
dc.contributor.authorFields, Christopher J
dc.contributor.authorWang, Leyi
dc.contributor.authorFredrickson, Richard
dc.contributor.authorBaughman, Melinda E
dc.contributor.authorChiu, Karen K
dc.contributor.authorChoi, Hannah
dc.contributor.authorScardina, Kevin R
dc.contributor.authorOwens, Alyssa N
dc.contributor.authorBroach, John
dc.contributor.authorBarton, Bruce
dc.contributor.authorLazar, Peter
dc.contributor.authorRobinson, Matthew L
dc.contributor.authorMostafa, Heba H
dc.contributor.authorManabe, Yukari C
dc.contributor.authorPekosz, Andrew
dc.contributor.authorMcManus, David D
dc.contributor.authorBrooke, Christopher B
dc.date.accessioned2022-10-25T17:54:26Z
dc.date.available2022-10-25T17:54:26Z
dc.date.issued2022-04-13
dc.identifier.citationKe R, Martinez PP, Smith RL, Gibson LL, Achenbach CJ, McFall S, Qi C, Jacob J, Dembele E, Bundy C, Simons LM, Ozer EA, Hultquist JF, Lorenzo-Redondo R, Opdycke AK, Hawkins C, Murphy RL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Conte A, Zhou R, Farjo M, Rendon G, Fields CJ, Wang L, Fredrickson R, Baughman ME, Chiu KK, Choi H, Scardina KR, Owens AN, Broach J, Barton B, Lazar P, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution. Open Forum Infect Dis. 2022 Apr 13;9(7):ofac192. doi: 10.1093/ofid/ofac192. PMID: 35791353; PMCID: PMC9047214.en_US
dc.identifier.issn2328-8957
dc.identifier.doi10.1093/ofid/ofac192en_US
dc.identifier.pmid35791353
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51206
dc.description.abstractBackground: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. Methods: We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. Results: The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. Conclusions: Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.en_US
dc.language.isoenen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.relation.urlhttps://doi.org/10.1093/ofid/ofac192en_US
dc.rights© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons. org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permis- sions@oup.com; Attribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSARS-CoV-2en_US
dc.subjectbreakthrough infectionsen_US
dc.subjectvaccinesen_US
dc.subjectviral dynamicsen_US
dc.subjectUMCCTS fundingen_US
dc.titleLongitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distributionen_US
dc.typeJournal Articleen_US
dc.source.journaltitleOpen forum infectious diseases
dc.source.volume9
dc.source.issue7
dc.source.beginpageofac192
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalOpen forum infectious diseases
refterms.dateFOA2022-10-25T17:54:27Z
dc.contributor.departmentCenter for Clinical and Translational Scienceen_US
dc.contributor.departmentEmergency Medicineen_US
dc.contributor.departmentMedicineen_US
dc.contributor.departmentPediatricsen_US
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US


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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons. org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permis- sions@oup.com; Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons. org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permis- sions@oup.com; Attribution-NonCommercial-NoDerivatives 4.0 International