Imaging features of toxicities associated with immune checkpoint inhibitors
Name:
Publisher version
UMass Chan Affiliations
RadiologyDocument Type
Journal ArticlePublication Date
2022-08-08Keywords
AIP, acute interstitial pneumonitisARDS, acute respiratory distress syndrome
CTCAE, Common Terminology Criteria for Adverse Events
CTLA-4 inhibitor, Cytotoxic T-lymphocyte antigen- 4 inhibitor
Colitis
FDA, Food and Drug Administration
Hepatitis
ICI, Immune check point inhibitor
Immune check point inhibitors toxicity
LGE, late Gadolinium enhancementNSCLC, non-small cell lung cancerNSIP, non-specific interstitial pneumoniaOP, organizing pneumoniaPD-1 inhibitor, programmed cell death-1 inhibitorPD-L1 inhibitor, programmed cell death ligand-1 inhibitorPFS, progression free survivalPancreatitisPneumonitisRRP, radiation recall pneumonitisirAE, immune-related adverse event
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The past decade has witnessed a change in landscape of cancer management with the advent of precision oncology. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and have played an important role in improving patient survival. While the patients are living longer, treatment with ICIs are sometimes associated with adverse effects, some of which could be fatal. Radiologists can play a crucial role by early identification of some of these adverse effects during restaging scans. Our paper focuses on the imaging features of commonly occurring ICI toxicities based on organ system.Source
Gosangi B, McIntosh L, Keraliya A, Irugu DVK, Baheti A, Khandelwal A, Thomas R, Braschi-Amirfarzan M. Imaging features of toxicities associated with immune checkpoint inhibitors. Eur J Radiol Open. 2022 Aug 8;9:100434. doi: 10.1016/j.ejro.2022.100434. PMID: 35967881; PMCID: PMC9372737.DOI
10.1016/j.ejro.2022.100434Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51263PubMed ID
35967881Rights
© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).; Attribution 4.0 InternationalDistribution License
http://creativecommons.org/licenses/by/4.0/Scopus Count
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Except where otherwise noted, this item's license is described as © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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