Sterilization of Polymeric Implants: Challenges and Opportunities
UMass Chan AffiliationsBiochemistry and Molecular Biotechnology
Orthopedics and Physical Rehabilitation
Document TypeJournal Article
MetadataShow full item record
AbstractDegradable and environmentally responsive polymers have been actively developed for drug delivery and regenerative medicine applications, yet inadequate consideration of their compatibility with terminal sterilization presents notable barriers to clinical translation. This Review discusses industry-established terminal sterilization methods and aseptic processing and contrasts them with innovative approaches aimed at preserving the integrity of polymeric implants. Regulatory guidelines, fiscal considerations, and potential pitfalls are discussed to encourage early integration of sterility regulatory considerations in material designs.
SourceHerczeg CK, Song J. Sterilization of Polymeric Implants: Challenges and Opportunities. ACS Appl Bio Mater. 2022 Nov 1. doi: 10.1021/acsabm.2c00793. Epub ahead of print. PMID: 36318175.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/51283