Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study
Authors
Qu, Ming DaKausar, Humera
Smith, Stephen
Lazar, Peter G
Kroll-Desrosiers, Aimee
Hollins, Carl
Barton, Bruce A
Ward, Doyle V
Ellison, Richard T
Document Type
Journal ArticlePublication Date
2022-03-18Keywords
BacteremiaStaphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Fevers
Vancomycin
Blood
Pneumonia
Skin infections
UMCCTS funding
Metadata
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Background: Panton-Valentine Leukocidin (PVL) toxin in Staphylococcus aureus has been associated with both severe pneumonia and skin and soft tissue infections. However, there are only limited data on how this virulence factor may influence the clinical course or complications of bacteremic S. aureus infections. Methods: Between September 2016 and March 2018, S. aureus isolates from clinical cultures from hospitals in an academic medical center underwent comprehensive genomic sequencing. Four hundred sixty-nine (29%) of 1681 S. aureus sequenced isolates were identified as containing the genes that encode for PVL. Case patients with one or more positive blood cultures for PVL were randomly matched with control patients having positive blood cultures with lukF/lukS-PV negative (PVL strains from a retrospective chart review). Results: 51 case and 56 control patients were analyzed. Case patients were more likely to have a history of injection drug use, while controls more likely to undergo hemodialysis. Isolates from 78.4% of case patients were methicillin resistant as compared to 28.6% from control patients. Case patients had a higher incidence of pneumonia and skin and soft tissue infection and longer duration of fever without differences in length of bacteremia. Clinical cure or expiration was comparable. Conclusions: These results are consistent with prior observations associating the PVL toxin with both community-acquired MRSA strains as well as severe staphylococcal pneumonia. The presence of the PVL toxin does not appear to otherwise influence the natural history of bacteremic S. aureus disease other than in prolonging the duration of fever.Source
Qu MD, Kausar H, Smith S, Lazar PG, Kroll-Desrosiers AR, Hollins C 3rd, Barton BA, Ward DV, Ellison RT 3rd. Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study. PLoS One. 2022 Mar 18;17(3):e0265476. doi: 10.1371/journal.pone.0265476. PMID: 35303019; PMCID: PMC8932578.DOI
10.1371/journal.pone.0265476Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51342PubMed ID
35303019Rights
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Distribution License
http://creativecommons.org/publicdomain/zero/1.0/ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0265476
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Except where otherwise noted, this item's license is described as This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.