Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction
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Authors
Al-Sadawi, MohammedAleem, Saadat
Aslam, Faisal
Jacobs, Robin
Stevens, Gregg A.
Almasry, Ibrahim
Singh, Abhijeet
Fan, Roger
Rashba, Eric
UMass Chan Affiliations
Lamar Soutter LibraryDocument Type
Journal ArticlePublication Date
2022-10-01Keywords
Cardiology and Cardiovascular MedicineAtrial fibrillation
Heart failure with preserved ejection fraction
Hospitalization
Mortality
Outcomes
Rate control
Rhythm control
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Background: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50% of all heart failure patients. Objective: Conduct a meta-analysis to assess the effects of rhythm control (ablation and/or antiarrhythmic medications) vs rate control on all-cause mortality in AF patients with HFpEF. Methods: Databases were searched for studies reporting the effect of rhythm control vs rate control on mortality in patients with HFpEF (Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL). The search was not restricted to time or publication status. The primary endpoint was all-cause mortality. The minimum duration of follow-up required for inclusion was 1 year. Results: The literature search identified 1210 candidate studies; 5 studies and 16,825 patients were included. The study population had 57% men with a mean age of 71± 2.5 years. Rhythm control for AF was associated with lower all-cause mortality (odds ratio 0.735, 95% confidence interval 0.665-0.813; P < .001) as compared to rate control. Conclusion: Rhythm control for AF in patients with HFpEF was associated with decreased all-cause mortality.Source
Al-Sadawi M, Aleem S, Aslam F, Jacobs R, Stevens G, Almasry I, Singh A, Fan R, Rashba E. Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction. Heart Rhythm O2. 2022 Jun 30;3(5):520-525. doi: 10.1016/j.hroo.2022.06.009. PMID: 36340484; PMCID: PMC9626734.DOI
10.1016/j.hroo.2022.06.009Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51357PubMed ID
36340484Rights
Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.hroo.2022.06.009
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Except where otherwise noted, this item's license is described as Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).