Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction
Stevens, Gregg A.
UMass Chan AffiliationsLamar Soutter Library
Document TypeJournal Article
KeywordsCardiology and Cardiovascular Medicine
Heart failure with preserved ejection fraction
MetadataShow full item record
AbstractBackground: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50% of all heart failure patients. Objective: Conduct a meta-analysis to assess the effects of rhythm control (ablation and/or antiarrhythmic medications) vs rate control on all-cause mortality in AF patients with HFpEF. Methods: Databases were searched for studies reporting the effect of rhythm control vs rate control on mortality in patients with HFpEF (Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL). The search was not restricted to time or publication status. The primary endpoint was all-cause mortality. The minimum duration of follow-up required for inclusion was 1 year. Results: The literature search identified 1210 candidate studies; 5 studies and 16,825 patients were included. The study population had 57% men with a mean age of 71± 2.5 years. Rhythm control for AF was associated with lower all-cause mortality (odds ratio 0.735, 95% confidence interval 0.665-0.813; P < .001) as compared to rate control. Conclusion: Rhythm control for AF in patients with HFpEF was associated with decreased all-cause mortality.
SourceAl-Sadawi M, Aleem S, Aslam F, Jacobs R, Stevens G, Almasry I, Singh A, Fan R, Rashba E. Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction. Heart Rhythm O2. 2022 Jun 30;3(5):520-525. doi: 10.1016/j.hroo.2022.06.009. PMID: 36340484; PMCID: PMC9626734.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/51357
RightsCopyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).