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    Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: One-Year Follow-up

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    Authors
    Nguyen, Thanh N
    Qureshi, Muhammad M
    Klein, Piers
    Yamagami, Hiroshi
    Mikulik, Robert
    Czlonkowska, Anna
    Abdalkader, Mohamad
    Sedova, Petra
    Sathya, Anvitha
    Lo, Hannah C
    Mansour, Ossama Yassin
    Vanguru, Husitha Reddy
    Lesaine, Emilie
    Tsivgoulis, Georgios
    Loochtan, Aaron I
    Demeestere, Jelle
    Uchino, Ken
    Inoa, Violiza
    Goyal, Nitin
    Charidimou, Andreas
    Siegler, James E
    Yaghi, Shadi
    Aguiar de Sousa, Diana
    Mohammaden, Mahmoud
    Haussen, Diogo C
    Kristoffersen, Espen Saxhaug
    Lereis, Virginia Pujol
    Scollo, Sergio Daniel
    Campbell, Bruce C V
    Ma, Alice
    Thomas, James Orton
    Parsons, Mark W
    Singhal, Shaloo
    Slater, Lee-Anne
    Martins, Rodrigo Tomazini
    Enzinger, Chris
    Gattringer, Thomas
    Rahman, Aminur
    Bonnet, Thomas
    Ligot, Noemie
    De Raedt, Sylvie
    Lemmens, Robin
    Vanacker, Peter
    Vandervorst, Fenne
    Conforto, Adriana Bastos
    Hidalgo, Raquel C T
    de Oliveira Neves, Luciana
    Martins, Rodrigo Targa
    Mora Cuervo, Daissy Liliana
    Rebello, Leticia C
    Santiago, Igor Bessa
    Lameirinhas da Silva, Isabelle
    Sakelarova, Teodora
    Kalpachki, Rosen
    Alexiev, Filip
    Catanese, Luciana
    Cora, Elena Adela
    Goyal, Mayank
    Hill, Michael D
    Kelly, Michael E
    Khosravani, Houman
    Lavoie, Pascale
    Peeling, Lissa
    Pikula, Aleksandra
    Rivera, Rodrigo
    Chen, Hui-Sheng
    Chen, Yimin
    Huo, Xiaochuan
    Miao, Zhongrong
    Yang, Shuiquan
    Bedekovic, Marina Roje
    Bralic, Marina
    Budincevic, Hrvoje
    Corredor-Quintero, Angel Basilio
    Lara-Sarabia, Osvaldo E
    Cabal, Martin
    Tenora, Dusan
    Fibrich, Petr
    Herzig, Roman
    Hlaváčová, Helena
    Hrabanovska, Emanuela
    Hlinovsky, David
    Jurak, Lubomir
    Kadlcikova, Jana
    Karpowicz, Igor
    Klecka, Lukas
    Kovar, Martin
    Lauer, David
    Neumann, Jiri
    Palouskova, Hana
    Reiser, Martin
    Rekova, Petra
    Rohan, Vladimir
    Skoda, Ondrej
    Škorňa, Miroslav
    Sobotková, Lenka
    Sramek, Martin
    Zakova, Lenka
    Christensen, Hanne
    Drenck, Nicolas
    Iversen, Helle Klingenberg
    Truelsen, Thomas Clement
    Wienecke, Troels
    Sobh, Khalid
    Ylikotila, Pauli
    Alpay, Kemal
    Strbian, Daniel
    Bernady, Patricia
    Casenave, Philippe
    Dan, Maria
    Faucheux, Jean-Marc
    Gentric, Jean-Christophe
    Magro, Elsa
    Sabben, Candice
    Reiner, Peggy
    Rouanet, Francois
    Bohmann, Ferdinand O
    Boskamp, Stefan
    Mbroh, Joshua
    Nagel, Simon
    Nolte, Christian
    Ringleb, Peter A
    Rosenkranz, Michael
    Poli, Sven
    Thomalla, Götz
    Karapanayiotides, Theodoros
    Koutroulou, Ioanna
    Kargiotis, Odysseas
    Palaiodimou, Lina
    Barrientos Guerra, Jose Dominguo
    Huded, Vikram
    Menon, Bindu
    Nagendra, Shashank
    Prajapati, Chintan
    Sylaja, P N
    Krishna Pramana, Nyoman Angga
    Sani, Achmad Firdaus
    Ghoreishi, Abdoreza
    Farhoudi, Mehdi
    Hokmabadi, Elyar Sadeghi
    Raya, Tariq Abu
    Kalmanovich, Shani Avnery
    Ronen, Levite
    Sabetay, Sergiu Ionut
    Acampa, Maurizio
    Adami, Alessandro
    Castellan, Lucio
    Longoni, Marco
    Ornello, Raffaele
    Renieri, Leonardo
    Bigliani, Claudia Rolla
    Romoli, Michele
    Sacco, Simona
    Salmaggi, Andrea
    Sangalli, Davide
    Zini, Andrea
    Doijiri, Ryosuke
    Fukuda, Hiroki
    Fujinaka, Toshiyuki
    Fujita, Kyohei
    Imamura, Hirotoshi
    Sakai, Nobuyuki
    Kanamaru, Takuya
    Kimura, Naoto
    Kono, Ryuhei
    Miyake, Kosuke
    Sakaguchi, Manabu
    Sakai, Kenichiro
    Sonoda, Kazutaka
    Todo, Kenichi
    Miyashita, Fumio
    Tokuda, Naoki
    Matsumaru, Yuji
    Matsumoto, Shoji
    Ohara, Nobuyuki
    Shindo, Seigo
    Takenobu, Yohei
    Yoshimoto, Takeshi
    Toyoda, Kazunori
    Uwatoko, Takeshi
    Yagita, Yoshiki
    Yamada, Takehiro
    Yamamoto, Nobuaki
    Yamamoto, Ryoo
    Yazawa, Yukako
    Sugiura, Yuri
    Waweru, Peter Kuria
    Baek, Jang-Hyun
    Lee, Si Baek
    Seo, Kwon-Duk
    Sohn, Sung-Il
    Arsovska, Anita Ante
    Chan, Yong Chieh
    Wan Zaidi, Wan Asyraf
    Jaafar, Ainul Syahrilfazli
    Gongora-Rivera, Fernando
    Martinez-Marino, Manuel
    Infante-Valenzuela, Adrian
    Groppa, Stanislav
    Leahu, Pavel
    Coutinho, Jonathan M
    Rinkel, Leon A
    Dippel, Diederik W J
    van Dam-Nolen, Dianne H K
    Ranta, Annemarei
    Wu, Teddy Y
    Adebayo, Tajudeen Temitayo
    Bello, Abiodun H
    Nwazor, Ernest Okwundu
    Sunmonu, Taofiki Ajao
    Wahab, Kolawole Wasiu
    Ronning, Ole Morten
    Sandset, Else Charlotte
    Al Hashimi, Amal M
    Ahmad, Saima
    Rashid, Umair
    Rodriguez-Kadota, Liliana
    Vences, Miguel Ángel
    Yalung, Patrick Matic
    Hao Dy, Jon Stewart
    Pineda-Franks, Maria Carissa
    Co, Christian Oliver
    Brola, Waldemar
    Debiec, Aleksander
    Dorobek, Malgorzata
    Karlinski, Michal Adam
    Labuz-Roszak, Beata M
    Lasek-Bal, Anetta
    Sienkiewicz-Jarosz, Halina
    Staszewski, Jacek
    Sobolewski, Piotr
    Wiacek, Marcin
    Zielinska-Turek, Justyna
    Araujo, Andre Pinho
    Rocha, Mariana
    Castro, Pedro
    Cruz, Vitor Tedim
    Ferreira, Paulo Venancio
    Ferreira, Patricia
    Nunes, Ana Paiva
    Fonseca, Luisa
    Marto, João Pedro
    Pinho E Melo, Teresa
    Rodrigues, Miguel
    Silva, M Luis
    Dimitriade, Adela
    Falup-Pecurariu, Cristian
    Hamid, May Adel
    Venketasubramanian, Narayanaswamy
    Krastev, Georgi
    Mako, Miroslav
    Ayo-Martin, Oscar
    Hernández-Fernández, Francisco
    Blasco, Jordi
    Rodríguez-Vázquez, Alejandro
    Cruz-Culebras, Antonio
    Moniche, Francisco
    Montaner, Joan
    Perez-Sanchez, Soledad
    García Sánchez, María Jesús
    Rodríguez, Marta Guillán
    Jood, Katarina
    Nordanstig, Annika
    Mazya, Michael V
    Moreira, Tiago T P
    Bernava, Gianmarco
    Beyeler, Morin
    Bolognese, Manuel
    Carrera, Emmanuel
    Dobrocky, Tomas
    Karwacki, Grzegorz Marek
    Keller, Emanuela
    Hsieh, Chang Yang
    Boonyakarnkul, Surawan
    Churojana, Anchalee
    Aykac, Ozlem
    Ozdemir, Atilla
    Bajrami, Arsida
    Senadim, Songul
    Hussain, Syed Irteza
    John, Seby
    Banerjee, Soma
    Kwan, Joseph
    Krishnan, Kailash
    Lenthall, Robert
    Matthews, Ashok
    Wong, Ken
    Zhang, Liqun
    Altschul, Dorothea
    Asif, Kaiz S
    Bahiru, Zeelalem
    Below, Kristine
    Biller, José
    Ruland, Sean
    Chaudry, Saqib A
    Chen, Michael
    Chebl, Alex
    Cibulka, Jackie
    Cistrunk, Leon
    Clark, Judith
    Colasurdo, Marco
    Czap, Alexandra
    de Havenon, Adam
    D'Amato, Salvatore
    Dharmadhikari, Sushrut
    Grimmett, Kasey B
    Dmytriw, Adam A
    Etherton, Mark R
    Ezepue, Chizoba
    Farooqui, Mudassir
    Feske, Steven K
    Fink, Lauren
    Gasimova, Ulviyya
    Guzik, Amy K
    Hakemi, Maryam
    Hovingh, Majesta
    Khan, Muhib
    Jillela, Dinesh
    Kan, Peter T
    Khatri, Rakesh
    Khawaja, Ayaz M
    Khoury, Naim N
    Kiley, Nicole L
    Kim, Benny S
    Kolikonda, Murali K
    Kuhn, Anna Luisa
    Lara, Stephanie
    Linares, Guillermo
    Linfante, Italo
    Lukovits, Timothy G
    Lycan, Sarah
    Male, Shailesh S
    Maali, Laith
    Mancin, John
    Masoud, Hesham
    Mohamed, Ghada A
    Monteiro, Andre
    Nahab, Fadi
    Nalleballe, Krishna
    Gutierrez, Santiago Ortega
    Puri, Ajit S
    Radaideh, Yazan
    Rahangdale, Rahul H
    Rai, Ansaar
    Ramakrishnan, Pankajavalli
    Reddy, Aravind B
    Rojas-Soto, Diana M
    Romero, Jose Rafael
    Rost, Natalia S
    Rothstein, Aaron
    Omran, Setareh Salehi
    Sheth, Sunil A
    Siddiqui, Adnan H
    Starosciak, Amy K
    Tarlov, Nicholas E
    Taylor, Robert A
    Wang, Michael J
    Wolfe, Jared
    Wong, Ka-Ho
    Le, Huynh Vu
    Nguyen, Quy Viet
    Pham, Thong Nhu
    Nguyen, Trung Thanh
    Phan, Hoang Thi
    Ton, Mai Duy
    Fischer, Urs
    Michel, Patrik
    Strambo, Davide
    Martins, Sheila O
    Zaidat, Osama O
    Nogueira, Raul G
    Show allShow less
    UMass Chan Affiliations
    Radiology
    Document Type
    Journal Article
    Publication Date
    2022-10-18
    Keywords
    COVID-19
    acute stroke
    intracranial hemorrhage
    intravenous thrombolysis
    ischemic stroke
    mechanical thrombectomy
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1212/wnl.0000000000201426
    Abstract
    Background and objectives: Declines in stroke admission, intravenous thrombolysis, and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the impact of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), intravenous thrombolysis (IVT), and mechanical thrombectomy over a one-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, intravenous thrombolysis treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 148,895 stroke admissions in the one-year immediately before compared to 138,453 admissions during the one-year pandemic, representing a 7% decline (95% confidence interval [95% CI 7.1, 6.9]; p<0.0001). ICH volumes declined from 29,585 to 28,156 (4.8%, [5.1, 4.6]; p<0.0001) and IVT volume from 24,584 to 23,077 (6.1%, [6.4, 5.8]; p<0.0001). Larger declines were observed at high volume compared to low volume centers (all p<0.0001). There was no significant change in mechanical thrombectomy volumes (0.7%, [0.6,0.9]; p=0.49). Stroke was diagnosed in 1.3% [1.31,1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82,2.97], 5,656/195,539) of all stroke hospitalizations. Discussion: There was a global decline and shift to lower volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared to the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year. Trial registration information: This study is registered under NCT04934020.
    Source
    Nguyen TN, Qureshi MM, Klein P, Yamagami H, Mikulik R, Czlonkowska A, Abdalkader M, Sedova P, Sathya A, Lo HC, Mansour OY, Vanguru HR, Lesaine E, Tsivgoulis G, Loochtan AI, Demeestere J, Uchino K, Inoa V, Goyal N, Charidimou A, Siegler JE, Yaghi S, Aguiar de Sousa D, Mohammaden M, Haussen DC, Kristoffersen ES, Lereis VP, Scollo SD, Campbell BCV, Ma A, Thomas JO, Parsons MW, Singhal S, Slater LA, Martins RT, Enzinger C, Gattringer T, Rahman A, Bonnet T, Ligot N, De Raedt S, Lemmens R, Vanacker P, Vandervorst F, Conforto AB, Hidalgo RCT, de Oliveira Neves L, Martins RT, Mora Cuervo DL, Rebello LC, Santiago IB, Lameirinhas da Silva I, Sakelarova T, Kalpachki R, Alexiev F, Catanese L, Cora EA, Goyal M, Hill MD, Kelly ME, Khosravani H, Lavoie P, Peeling L, Pikula A, Rivera R, Chen HS, Chen Y, Huo X, Miao Z, Yang S, Bedekovic MR, Bralic M, Budincevic H, Corredor-Quintero AB, Lara-Sarabia OE, Cabal M, Tenora D, Fibrich P, Herzig R, Hlaváčová H, Hrabanovska E, Hlinovsky D, Jurak L, Kadlcikova J, Karpowicz I, Klecka L, Kovar M, Lauer D, Neumann J, Palouskova H, Reiser M, Rekova P, Rohan V, Skoda O, Škorňa M, Sobotková L, Sramek M, Zakova L, Christensen H, Drenck N, Iversen HK, Truelsen TC, Wienecke T, Sobh K, Ylikotila P, Alpay K, Strbian D, Bernady P, Casenave P, Dan M, Faucheux JM, Gentric JC, Magro E, Sabben C, Reiner P, Rouanet F, Bohmann FO, Boskamp S, Mbroh J, Nagel S, Nolte C, Ringleb PA, Rosenkranz M, Poli S, Thomalla G, Karapanayiotides T, Koutroulou I, Kargiotis O, Palaiodimou L, Barrientos Guerra JD, Huded V, Menon B, Nagendra S, Prajapati C, Sylaja PN, Krishna Pramana NA, Sani AF, Ghoreishi A, Farhoudi M, Hokmabadi ES, Raya TA, Kalmanovich SA, Ronen L, Sabetay SI, Acampa M, Adami A, Castellan L, Longoni M, Ornello R, Renieri L, Bigliani CR, Romoli M, Sacco S, Salmaggi A, Sangalli D, Zini A, Doijiri R, Fukuda H, Fujinaka T, Fujita K, Imamura H, Sakai N, Kanamaru T, Kimura N, Kono R, Miyake K, Sakaguchi M, Sakai K, Sonoda K, Todo K, Miyashita F, Tokuda N, Matsumaru Y, Matsumoto S, Ohara N, Shindo S, Takenobu Y, Yoshimoto T, Toyoda K, Uwatoko T, Yagita Y, Yamada T, Yamamoto N, Yamamoto R, Yazawa Y, Sugiura Y, Waweru PK, Baek JH, Lee SB, Seo KD, Sohn SI, Arsovska AA, Chan YC, Wan Zaidi WA, Jaafar AS, Gongora-Rivera F, Martinez-Marino M, Infante-Valenzuela A, Groppa S, Leahu P, Coutinho JM, Rinkel LA, Dippel DWJ, van Dam-Nolen DHK, Ranta A, Wu TY, Adebayo TT, Bello AH, Nwazor EO, Sunmonu TA, Wahab KW, Ronning OM, Sandset EC, Al Hashimi AM, Ahmad S, Rashid U, Rodriguez-Kadota L, Vences MÁ, Yalung PM, Hao Dy JS, Pineda-Franks MC, Co CO, Brola W, Debiec A, Dorobek M, Karlinski MA, Labuz-Roszak BM, Lasek-Bal A, Sienkiewicz-Jarosz H, Staszewski J, Sobolewski P, Wiacek M, Zielinska-Turek J, Araujo AP, Rocha M, Castro P, Cruz VT, Ferreira PV, Ferreira P, Nunes AP, Fonseca L, Marto JP, Pinho E Melo T, Rodrigues M, Silva ML, Dimitriade A, Falup-Pecurariu C, Hamid MA, Venketasubramanian N, Krastev G, Mako M, Ayo-Martin O, Hernández-Fernández F, Blasco J, Rodríguez-Vázquez A, Cruz-Culebras A, Moniche F, Montaner J, Perez-Sanchez S, García Sánchez MJ, Rodríguez MG, Jood K, Nordanstig A, Mazya MV, Moreira TTP, Bernava G, Beyeler M, Bolognese M, Carrera E, Dobrocky T, Karwacki GM, Keller E, Hsieh CY, Boonyakarnkul S, Churojana A, Aykac O, Ozdemir A, Bajrami A, Senadim S, Hussain SI, John S, Banerjee S, Kwan J, Krishnan K, Lenthall R, Matthews A, Wong K, Zhang L, Altschul D, Asif KS, Bahiru Z, Below K, Biller J, Ruland S, Chaudry SA, Chen M, Chebl A, Cibulka J, Cistrunk L, Clark J, Colasurdo M, Czap A, de Havenon A, D'Amato S, Dharmadhikari S, Grimmett KB, Dmytriw AA, Etherton MR, Ezepue C, Farooqui M, Feske SK, Fink L, Gasimova U, Guzik AK, Hakemi M, Hovingh M, Khan M, Jillela D, Kan PT, Khatri R, Khawaja AM, Khoury NN, Kiley NL, Kim BS, Kolikonda MK, Kuhn AL, Lara S, Linares G, Linfante I, Lukovits TG, Lycan S, Male SS, Maali L, Mancin J, Masoud H, Mohamed GA, Monteiro A, Nahab F, Nalleballe K, Gutierrez SO, Puri AS, Radaideh Y, Rahangdale RH, Rai A, Ramakrishnan P, Reddy AB, Rojas-Soto DM, Romero JR, Rost NS, Rothstein A, Omran SS, Sheth SA, Siddiqui AH, Starosciak AK, Tarlov NE, Taylor RA, Wang MJ, Wolfe J, Wong KH, Le HV, Nguyen QV, Pham TN, Nguyen TT, Phan HT, Ton MD, Fischer U, Michel P, Strambo D, Martins SO, Zaidat OO, Nogueira RG. Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: One-Year Follow-up. Neurology. 2022 Oct 18:10.1212/WNL.0000000000201426. doi: 10.1212/WNL.0000000000201426. Epub ahead of print. PMID: 36257718.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/51425
    PubMed ID
    36257718
    Rights
    © 2022 American Academy of Neurology.
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