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dc.contributor.authorSoni, Apurv
dc.contributor.authorHerbert, Carly
dc.contributor.authorFilippaios, Andreas
dc.contributor.authorBroach, John
dc.contributor.authorColubri, Andrés
dc.contributor.authorFahey, Nisha
dc.contributor.authorWoods, Kelsey
dc.contributor.authorNanavati, Janvi
dc.contributor.authorWright, Colton
dc.contributor.authorOrwig, Taylor
dc.contributor.authorGilliam, Karen
dc.contributor.authorKheterpal, Vik
dc.contributor.authorSuvarna, Thejas
dc.contributor.authorNowak, Chris
dc.contributor.authorSchrader, Summer
dc.contributor.authorLin, Honghuang
dc.contributor.authorO'Connor, Laurel
dc.contributor.authorPretz, Caitlin
dc.contributor.authorAyturk, Didem
dc.contributor.authorOrvek, Elizabeth
dc.contributor.authorFlahive, Julie
dc.contributor.authorLazar, Peter
dc.contributor.authorShi, Qiming
dc.contributor.authorAchenbach, Chad
dc.contributor.authorMurphy, Robert
dc.contributor.authorRobinson, Matthew
dc.contributor.authorGibson, Laura L
dc.contributor.authorStamegna, Pamela
dc.contributor.authorHafer, Nathaniel
dc.contributor.authorLuzuriaga, Katherine
dc.contributor.authorBarton, Bruce
dc.contributor.authorHeetderks, William
dc.contributor.authorManabe, Yukari C
dc.contributor.authorMcManus, David
dc.date.accessioned2022-12-13T18:03:12Z
dc.date.available2022-12-13T18:03:12Z
dc.date.issued2022-10-11
dc.identifier.citationSoni A, Herbert C, Filippaios A, Broach J, Colubri A, Fahey N, Woods K, Nanavati J, Wright C, Orwig T, Gilliam K, Kheterpal V, Suvarna T, Nowak C, Schrader S, Lin H, O'Connor L, Pretz C, Ayturk D, Orvek E, Flahive J, Lazar P, Shi Q, Achenbach C, Murphy R, Robinson M, Gibson L, Stamegna P, Hafer N, Luzuriaga K, Barton B, Heetderks W, Manabe YC, McManus D. Comparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2 : A Secondary Analysis From a Serial Home Self-testing Study. Ann Intern Med. 2022 Oct 11:M22-0760. doi: 10.7326/M22-0760. Epub ahead of print. PMID: 36215709; PMCID: PMC9578286.en_US
dc.identifier.eissn1539-3704
dc.identifier.doi10.7326/M22-0760en_US
dc.identifier.pmid36215709
dc.identifier.urihttp://hdl.handle.net/20.500.14038/51447
dc.description.abstractBackground: It is important to document the performance of rapid antigen tests (Ag-RDTs) in detecting SARS-CoV-2 variants. Objective: To compare the performance of Ag-RDTs in detecting the Delta (B.1.617.2) and Omicron (B.1.1.529) variants of SARS-CoV-2. Design: Secondary analysis of a prospective cohort study that enrolled participants between 18 October 2021 and 24 January 2022. Participants did Ag-RDTs and collected samples for reverse transcriptase polymerase chain reaction (RT-PCR) testing every 48 hours for 15 days. Setting: The parent study enrolled participants throughout the mainland United States through a digital platform. All participants self-collected anterior nasal swabs for rapid antigen testing and RT-PCR testing. All Ag-RDTs were completed at home, whereas nasal swabs for RT-PCR were shipped to a central laboratory. Participants: Of 7349 participants enrolled in the parent study, 5779 asymptomatic persons who tested negative for SARS-CoV-2 on day 1 of the study were eligible for this substudy. Measurements: Sensitivity of Ag-RDTs on the same day as the first positive (index) RT-PCR result and 48 hours after the first positive RT-PCR result. Results: A total of 207 participants were positive on RT-PCR (58 Delta, 149 Omicron). Differences in sensitivity between variants were not statistically significant (same day: Delta, 15.5% [95% CI, 6.2% to 24.8%] vs. Omicron, 22.1% [CI, 15.5% to 28.8%]; at 48 hours: Delta, 44.8% [CI, 32.0% to 57.6%] vs. Omicron, 49.7% [CI, 41.6% to 57.6%]). Among 109 participants who had RT-PCR-positive results for 48 hours, rapid antigen sensitivity did not differ significantly between Delta- and Omicron-infected participants (48-hour sensitivity: Delta, 81.5% [CI, 66.8% to 96.1%] vs. Omicron, 78.0% [CI, 69.1% to 87.0%]). Only 7.2% of the 69 participants with RT-PCR-positive results for shorter than 48 hours tested positive by Ag-RDT within 1 week; those with Delta infections remained consistently negative on Ag-RDTs. Limitation: A testing frequency of 48 hours does not allow a finer temporal resolution of the analysis of test performance, and the results of Ag-RDTs are based on self-report. Conclusion: The performance of Ag-RDTs in persons infected with the SARS-CoV-2 Omicron variant is not inferior to that in persons with Delta infections. Serial testing improved the sensitivity of Ag-RDTs for both variants. The performance of rapid antigen testing varies on the basis of duration of RT-PCR positivity. Primary funding source: National Heart, Lung, and Blood Institute of the National Institutes of Health.en_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Internal Medicineen_US
dc.relation.urlhttps://doi.org/10.7326/m22-0760en_US
dc.subjectUMCCTS funding
dc.titleComparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2 : A Secondary Analysis From a Serial Home Self-testing Studyen_US
dc.typeJournal Articleen_US
dc.source.journaltitleAnnals of internal medicine
dc.source.countryUnited States
dc.identifier.journalAnnals of internal medicine
dc.contributor.departmentCenter for Clinical and Translational Scienceen_US
dc.contributor.departmentEmergency Medicineen_US
dc.contributor.departmentMedicineen_US
dc.contributor.departmentMicrobiology and Physiological Systemsen_US
dc.contributor.departmentMorningside Graduate School of Biomedical Sciencesen_US
dc.contributor.departmentPediatricsen_US
dc.contributor.departmentPopulation and Quantitative Health Sciencesen_US
dc.contributor.departmentProgram in Bioinformatics and Integrative Biologyen_US
dc.contributor.departmentProgram in Molecular Medicineen_US


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